SAFB2

SAFB2

Identifiers

SAFB2, scaffold attachment factor B2

External IDs

MGI: 2146808 HomoloGene: 35210 GeneCards: SAFB2

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	No data available	Start	5,586,999 bp^[1]
Band	No data available	End	5,624,046 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	No data available	Start	56,560,965 bp^[2]
Band	No data available	End	56,584,585 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• DNA binding • nucleic acid binding • identical protein binding • protein binding • double-stranded DNA binding • RNA binding • sequence-specific DNA binding
Cellular component	• extracellular exosome • nucleoplasm • cytoplasm • intracellular membrane-bounded organelle • nucleus • nuclear body
Biological process	• regulation of transcription, DNA-templated • transcription, DNA-templated • Sertoli cell differentiation • regulation of transcription from RNA polymerase II promoter • regulation of androgen receptor signaling pathway • regulation of mRNA processing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


9667


224902


ENSG00000130254


ENSMUSG00000042625


Q14151


Q80YR5

RefSeq (mRNA)


NM_014649


NM_001029979

RefSeq (protein)


NP_055464


NP_001025150

Location (UCSC)

Chr 19: 5.59 – 5.62 Mb

Chr 19: 56.56 – 56.58 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Scaffold attachment factor B2 is a protein that in humans is encoded by the SAFB2 gene.^[5]^[6]

Interactions

SAFB2 has been shown to interact with Estrogen receptor alpha^[5] and SAFB.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130254 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042625 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 3 Townson SM, Dobrzycka KM, Lee AV, Air M, Deng W, Kang K, Jiang S, Kioka N, Michaelis K, Oesterreich S (May 2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. PMID 12660241. doi:10.1074/jbc.M212988200.
↑ "Entrez Gene: SAFB2 scaffold attachment factor B2".

Further reading

Oesterreich S (2003). "Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?". J. Cell. Biochem. 90 (4): 653–61. PMID 14587024. doi:10.1002/jcb.10685.
Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. PMID 8590280. doi:10.1093/dnares/2.4.167.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics. 3 (11): 1093–101. PMID 15345747. doi:10.1074/mcp.M400085-MCP200.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.

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