S100A12

S100A12
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1E8A, 1GQM, 1ODB, 2M9G, 2WC8, 2WCB, 2WCE, 2WCF
Identifiers
Aliases	S100A12, CAAF1, CAGC, CGRP, ENRAGE, MRP-6, MRP6, p6, S100 calcium binding protein A12
External IDs	HomoloGene: 48361 GeneCards: S100A12
Gene location (Human) Chr. Chromosome 1 (human)[1] Band No data available Start 153,373,706 bp[1] End 153,375,649 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • zinc ion binding • metal ion binding • protein binding • RAGE receptor binding • copper ion binding Cellular component • cytoplasm • cytosol • membrane • plasma membrane • extracellular region • cytoskeleton • nucleus • secretory granule lumen Biological process • mast cell activation • positive regulation of inflammatory response • positive regulation of MAP kinase activity • monocyte chemotaxis • immune system process • cytokine secretion • defense response to fungus • neutrophil chemotaxis • defense response to bacterium • positive regulation of NF-kappaB transcription factor activity • positive regulation of I-kappaB kinase/NF-kappaB signaling • xenobiotic metabolic process • innate immune response • inflammatory response • neutrophil degranulation • killing of cells of other organism • antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6283	n/a
Ensembl	ENSG00000163221	n/a
UniProt	P80511	n/a
RefSeq (mRNA)	NM_005621	n/a
RefSeq (protein)	NP_005612	n/a
Location (UCSC)	Chr 1: 153.37 – 153.38 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene.^[3][4] It is also known as calgranulin C.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.^[4]

References

Further reading