RybB RNA

RybB RNA

Identifiers
Symbol RybB
Rfam RF00110
Other data
RNA type Gene; sRNA
Domain(s) Bacteria
SO 0000655

RybB is a small non-coding RNA was identified in a large scale screen of Escherichia coli.[1] The function of this short RNA has been studied using a transcriptomic approach and kinetic analyses of target mRNA decay in vivo. RybB was identified as a factor that selectively accelerates the decay of multiple major omp mRNAs upon induction of the envelope stress response.[2] This RNA has been shown to bind to the Hfq protein.

In Salmonella, direct interactions for RybB with the following targets have been verified experimentally: STM2391 (fadL), STM1070 (ompA), STM2267 (ompC), STM1572 (ompD), STM0999 (ompF), STM1473 (ompN), STM1995 (ompS), STM1732 (ompW), STM0413 (tsx), STM0687 (ybfM, chiP) and STM1530.[3][4][5][6]

In Escherichia coli, direct interactions for RybB with the following targets have been verified experimentally: b0805 (fiu), b0721 (sdhC), b2215 (ompC), b1256 (ompW), b2594 (rluD) and b0081 (mraZ).[7][8][9][10]

See also

References

  1. ↑ Wassarman, KM; Repoila F; Rosenow C; Storz G; Gottesman S (2001). "Identification of novel small RNAs using comparative genomics and microarrays". Genes Dev. 15 (13): 1637–1651. PMC 312727 Freely accessible. PMID 11445539. doi:10.1101/gad.901001.
  2. ↑ Papenfort, K; Pfeiffer V; Mika F; Lucchini S; Hinton JC; Vogel J (2006). "SigmaE-dependent small RNAs of Salmonella respond to membrane stress by accelerating global omp mRNA decay". Mol Microbiol. 62 (6): 1674–1688. PMC 1804206 Freely accessible. PMID 17427289. doi:10.1111/j.1365-2958.2006.05524.x.
  3. ↑ Papenfort K, Bouvier M, Mika F, Sharma CM, Vogel J (2010). "Evidence for an autonomous 5' target recognition domain in an Hfq-associated small RNA.". Proc Natl Acad Sci U S A. 107 (47): 20435–20440. PMC 2996696 Freely accessible. PMID 21059903. doi:10.1073/pnas.1009784107.
  4. ↑ Bouvier M, Sharma CM, Mika F, Nierhaus KH, Vogel J (2008). "Small RNA binding to 5' mRNA coding region inhibits translational initiation.". Mol Cell. 32 (6): 827–37. PMID 19111662. doi:10.1016/j.molcel.2008.10.027.
  5. ↑ Balbontín R, Fiorini F, Figueroa-Bossi N, Casadesús J, Bossi L (2010). "Recognition of heptameric seed sequence underlies multi-target regulation by RybB small RNA in Salmonella enterica.". Mol Microbiol. 78 (2): 380–94. PMID 20979336. doi:10.1111/j.1365-2958.2010.07342.x.
  6. ↑ Wright, PR (2012). hIntaRNA - Comparative prediction of sRNA targets in prokaryotes. (Diploma). Albert-Ludwigs-Universität Freiburg.
  7. ↑ Gogol EB, Rhodius VA, Papenfort K, Vogel J, Gross CA (2011). "Small RNAs endow a transcriptional activator with essential repressor functions for single-tier control of a global stress regulon.". Proc Natl Acad Sci U S A. 108 (31): 12875–12880. PMC 3150882 Freely accessible. PMID 21768388. doi:10.1073/pnas.1109379108.
  8. ↑ Desnoyers G, Massé E (2012). "Noncanonical repression of translation initiation through small RNA recruitment of the RNA chaperone Hfq.". Genes Dev. 26 (7): 726–739. PMC 3323883 Freely accessible. PMID 22474262. doi:10.1101/gad.182493.111.
  9. ↑ Johansen J, Rasmussen AA, Overgaard M, Valentin-Hansen P (2006). "Conserved small non-coding RNAs that belong to the sigmaE regulon: role in down-regulation of outer membrane proteins.". J Mol Biol. 364 (1): 1–8. PMID 17007876. doi:10.1016/j.jmb.2006.09.004.
  10. ↑ Wright PR, Richter AS, Papenfort K, Mann M, Vogel J, Hess WR, Backofen R, Georg J (2013). "Comparative genomics boosts target prediction for bacterial small RNAs.". Proc Natl Acad Sci U S A. 110 (37): E3487–E3496. PMC 3773804 Freely accessible. PMID 23980183. doi:10.1073/pnas.1303248110.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.