Ruplizumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | CD154 |
| Clinical data | |
| Trade names | Antova |
| ATC code |
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| Identifiers | |
| CAS Number | |
| ChemSpider |
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Ruplizumab (trade name Antova) is a humanized monoclonal antibody intended for the treatment of rheumatic diseases like systemic lupus erythematosus and lupus nephritis. A study showed that the drug was associated with life-threatening thromboembolisms,[1] while another study only found thrombocytopenia.[2]
References
- ↑ Liossis, SN; Sfikakis, PP (2004). "Costimulation blockade in the treatment of rheumatic diseases". BioDrugs. 18 (2): 95–102. PMID 15046525. doi:10.2165/00063030-200418020-00003.
- ↑ Nakamura, M; Tanaka, Y; Satoh, T; Kawai, M; Hirakata, M; Kaburaki, J; Kawakami, Y; Ikeda, Y; Kuwana, M (2006). "Autoantibody to CD40 ligand in systemic lupus erythematosus: association with thrombocytopenia but not thromboembolism". Rheumatology (Oxford, England). 45 (2): 150–6. PMID 16188945. doi:10.1093/rheumatology/kei118.
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