Rifampicin/isoniazid/pyrazinamide

Rifampicin/isoniazid/pyrazinamide
Combination of
Rifampicin Rifamycin antibiotic
Isoniazid Anti-tuberculosis medication
Pyrazinamide Anti-tuberculosis medication
Clinical data
Trade names Rifater, Trifazid, others
AHFS/Drugs.com FDA Professional Drug Information
Pregnancy
category
  • C
Routes of
administration		 by mouth
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
PubChem CID
ChemSpider
  • none
KEGG
  (verify)

Rifampicin/isoniazid/pyrazinamide, also known as rifampin/isoniazid/pyrazinamide, is a medication used to treat tuberculosis. It is a fixed dose combination of rifampicin, isoniazid, and pyrazinamide. It is used either by itself or along with other antituberculosis medication. It is taken by mouth.[1]

Side effects are those of the underlying medications.[1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness.[2] Severe side effects include liver problems. Use in those under the age of 15 may not be appropriate. It is unclear if use in pregnancy is safe for the baby.[3]

Rifampicin/isoniazid/pyrazinamide was approved for medical use in the United States in 1994.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[4] The wholesale cost in the developing world is about 3.93 USD a month.[5] In the United Kingdom a month of treatment costs the NHS about 39.51 pounds.[6]

Medical uses

The purpose of the fixed dose combination is to make it easier for people to take their medication; but also to ensure that if people forget to take one or two of their drugs, they do not then develop resistance to the remaining drugs.

Society and culture

It is manufactured by Aventis.

See also

References

  1. 1 2 WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 143. ISBN 9789241547659. Retrieved 8 December 2016.
  2. ↑ "Rifater Side Effects in Detail - Drugs.com". www.drugs.com. Retrieved 18 December 2016.
  3. 1 2 "Rifater - FDA prescribing information, side effects and uses". www.drugs.com. October 2016. Retrieved 18 December 2016.
  4. ↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
  5. ↑ "Rifampicin + Isoniazid + Pyrazinamide". International Drug Price Indicator Guide. Retrieved 8 December 2016.
  6. ↑ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 403. ISBN 9780857111562.
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