Renal oncocytoma

Renal oncocytoma
Micrograph of a renal oncocytoma.
Classification and external resources
ICD-O M8290/0
DiseasesDB 31956
Renal oncocytoma of the right kidney at CT.

A renal oncocytoma is a tumour of the kidney made up of oncocytes, a special kind of cell.[1][2]

Signs and symptoms

Renal oncocytomas are often asymptomatic and are frequently discovered by chance on a CT or ultrasound of the abdomen. Possible signs and symptoms of a renal oncocytoma include blood in the urine, flank pain, and an abdominal mass.

Pathophysiology

Renal oncocytoma is thought to arise from the intercalated cells of collecting ducts of the kidney. It represent 5% to 15% of surgically resected renal neoplasms. Ultrastructurally, the eosinophilic cells have numerous mitochondria.

Histologic appearance

An oncocytoma is an epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing nuclei with large nucleoli with excessive amounts of mitochondria.

Diagnosis

Gross appearance of a renal oncocytoma (left of image) and a slice of a normal kidney (right of image). Note the rounded contour, the mahogany colour and the central scar.

In gross appearance, the tumors are tan or mahogany brown, well circumscribed and contain a central scar. They may achieve a large size (up to 12 cm in diameter).

The main differential diagnosis of renal oncocytoma is chromophobe renal cell carcinoma oncocytic variant, which like the renal oncocytoma has eosinophilic cytoplasm, but has perinuclear clearing and, typically, some degree of nuclear atypia.

Immunohistochemical profile

[3]

Treatment

Renal oncocytoma is considered benign, cured by nephrectomy. There are some familial cases in which these tumors are multicentric rather than solitary.[4] However, they may be resected to exclude a malignant tumor, e.g. renal cell carcinoma.

See also

Additional images

References

  1. ↑ Coburn V, Radfar A, Snook D, Mahalingam M (2007). "Cutaneous oncocytoma - a report of three cases and review of the literature". J. Cutan. Pathol. 34 (4): 355–9. PMID 17381809. doi:10.1111/j.1600-0560.2006.00620.x.
  2. ↑ "Atlas of Genetics and Cytogenetics in Oncology and Haematology - Thyroid:oncocytic tumors". Retrieved 2009-02-01.
  3. ↑ [Renal Neoplasms: An Update on Immunohistochemical and Histochemical Features http://www.dako.com/08066_12may10_webchapter26.pdf]
  4. ↑ Robbins pathology, page 1015
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