RUVBL2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CQA, 2XSZ, 3UK6

Identifiers

Aliases

RUVBL2, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B, CGI-46, ECP-51, TAP54-beta, RuvB like AAA ATPase 2

External IDs

MGI: 1342299 HomoloGene: 4856 GeneCards: RUVBL2

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	No data available	Start	48,993,448 bp^[1]
Band	No data available	End	49,015,995 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	No data available	Start	45,421,760 bp^[2]
Band	No data available	End	45,438,096 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• RNA polymerase II distal enhancer sequence-specific DNA binding • nucleotide binding • ATP-dependent 5'-3' DNA helicase activity • helicase activity • unfolded protein binding • ATP-dependent DNA helicase activity • DNA helicase activity • ATPase activity • protein binding • identical protein binding • chromatin DNA binding • ATP binding • hydrolase activity • RNA polymerase II core promoter sequence-specific DNA binding • TFIID-class transcription factor binding • protein homodimerization activity • ADP binding • ATPase binding
Cellular component	• nuclear euchromatin • membrane • Ino80 complex • nuclear matrix • NuA4 histone acetyltransferase complex • intracellular • nucleoplasm • MLL1 complex • extracellular exosome • nucleus • Swr1 complex • R2TP complex • cytoplasm • centrosome • cytosol • intracellular ribonucleoprotein complex
Biological process	• chromatin remodeling • DNA recombination • regulation of transcription, DNA-templated • transcriptional activation by promoter-enhancer looping • cellular response to UV • histone H2A acetylation • cellular response to estradiol stimulus • transcription, DNA-templated • positive regulation of histone acetylation • cellular response to DNA damage stimulus • establishment of protein localization to chromatin • protein folding • positive regulation of telomerase RNA localization to Cajal body • histone H4 acetylation • regulation of growth • negative regulation of estrogen receptor binding • DNA repair • positive regulation of transcription from RNA polymerase II promoter • DNA duplex unwinding • covalent chromatin modification • box C/D snoRNP assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10856


20174

Ensembl


ENSG00000183207


ENSMUSG00000003868

UniProt


Q9Y230


Q9WTM5

RefSeq (mRNA)


NM_006666 NM_001321190 NM_001321191


NM_011304

RefSeq (protein)


NP_001308119 NP_001308120 NP_006657


NP_035434

Location (UCSC)

Chr 19: 48.99 – 49.02 Mb

Chr 19: 45.42 – 45.44 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.

Function

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory.^[5] This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.^[6]

Interactions

RUVBL2 has been shown to interact with RuvB-like 1^[7] and Activating transcription factor 2.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183207 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003868 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR (Feb 2007). "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex". Journal of Molecular Biology. 366 (1): 179–92. PMID 17157868. doi:10.1016/j.jmb.2006.11.030.
↑ "Entrez Gene: RUVBL2 RuvB-like 2 (E. coli)".
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.
↑ Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z (Dec 2001). "TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage". Molecular and Cellular Biology. 21 (24): 8398–413. PMC 100004 . PMID 11713276. doi:10.1128/MCB.21.24.8398-8413.2001.

Doyon Y, Côté J (Apr 2004). "The highly conserved and multifunctional NuA4 HAT complex". Current Opinion in Genetics & Development. 14 (2): 147–54. PMID 15196461. doi:10.1016/j.gde.2004.02.009.
Kanemaki M, Kurokawa Y, Matsu-ura T, Makino Y, Masani A, Okazaki K, Morishita T, Tamura TA (Aug 1999). "TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a". The Journal of Biological Chemistry. 274 (32): 22437–44. PMID 10428817. doi:10.1074/jbc.274.32.22437.
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Wood MA, McMahon SB, Cole MD (Feb 2000). "An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc". Molecular Cell. 5 (2): 321–30. PMID 10882073. doi:10.1016/S1097-2765(00)80427-X.
Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J, Nakatani Y (Aug 2000). "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis". Cell. 102 (4): 463–73. PMID 10966108. doi:10.1016/S0092-8674(00)00051-9.
Parfait B, Giovangrandi Y, Asheuer M, Laurendeau I, Olivi M, Vodovar N, Vidaud D, Vidaud M, Bièche I (2000). "Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3". Annales de Génétique. 43 (2): 69–74. PMID 10998447. doi:10.1016/S0003-3995(00)01016-9.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Bauer A, Chauvet S, Huber O, Usseglio F, Rothbächer U, Aragnol D, Kemler R, Pradel J (Nov 2000). "Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity". The EMBO Journal. 19 (22): 6121–30. PMC 305835 . PMID 11080158. doi:10.1093/emboj/19.22.6121.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z (Dec 2001). "TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage". Molecular and Cellular Biology. 21 (24): 8398–413. PMC 100004 . PMID 11713276. doi:10.1128/MCB.21.24.8398-8413.2001.
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RUVBL2

Function

Interactions

References

Further reading