RTN3

Identifiers

RTN3, ASYIP, HAP, NSPL2, NSPLII, RTN3-A1, reticulon 3

External IDs

MGI: 1339970 HomoloGene: 24934 GeneCards: RTN3

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	No data available	Start	63,681,446 bp^[1]
Band	No data available	End	63,759,891 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	No data available	Start	7,425,901 bp^[2]
Band	No data available	End	7,483,289 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding
Cellular component	• integral component of membrane • Golgi membrane • Golgi apparatus • extracellular exosome • endoplasmic reticulum • membrane • endoplasmic reticulum membrane • plasma membrane • extracellular space
Biological process	• endoplasmic reticulum tubular network organization • viral process • vesicle-mediated transport • apoptotic process • endoplasmic reticulum tubular network formation • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10313


20168

Ensembl


ENSG00000133318


ENSMUSG00000024758

UniProt


O95197


Q9ES97

RefSeq (mRNA)

NM_001265589 NM_001265590 NM_001265591 NM_006054 NM_201428
NM_201429 NM_201430

NM_001003930 NM_001003933 NM_001003934 NM_001271486 NM_001271487
NM_053076

RefSeq (protein)

NP_001252518 NP_001252519 NP_001252520 NP_006045 NP_958831
NP_958832 NP_958833


NP_001003933 NP_001003934 NP_001258415 NP_001258416 NP_444306

Location (UCSC)

Chr 11: 63.68 – 63.76 Mb

Chr 11: 7.43 – 7.48 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Reticulon-3 is a protein that in humans is encoded by the RTN3 gene.^[5]^[6]

The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues (see, e.g., RTN1; MIM 600865).[supplied by OMIM]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133318 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024758 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Moreira EF, Jaworski CJ, Rodriguez IR (Jul 1999). "Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13". Genomics. 58 (1): 73–81. PMID 10331947. doi:10.1006/geno.1999.5807.
1 2 "Entrez Gene: RTN3 reticulon 3".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Qu X, Qi Y, Qi B (2002). "Generation of multiple mRNA transcripts from the novel human apoptosis-inducing gene hap by alternative polyadenylation utilization and the translational activation function of 3' untranslated region". Arch. Biochem. Biophys. 400 (2): 233–44. PMID 12054434. doi:10.1016/S0003-9861(02)00016-4.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Qi B, Qi Y, Watari A, et al. (2003). "Pro-apoptotic ASY/Nogo-B protein associates with ASYIP". J. Cell. Physiol. 196 (2): 312–8. PMID 12811824. doi:10.1002/jcp.10297.
Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family". FASEB J. 17 (10): 1238–47. PMID 12832288. doi:10.1096/fj.02-1166hyp.
Di Sano F, Fazi B, Citro G, et al. (2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–5. PMID 12873973.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Huang X, Yang H, Zhou Y, et al. (2004). "Overexpression of human reticulon 3 (hRTN3) in astrocytoma". Clin. Neuropathol. 23 (1): 1–7. PMID 14986927.
Hu Y, Fang X, Dunham SM, et al. (2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling". J. Biol. Chem. 279 (28): 29325–35. PMID 15117958. doi:10.1074/jbc.M311144200.
He W, Lu Y, Qahwash I, et al. (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959–65. PMID 15286784. doi:10.1038/nm1088.
Di Scala F, Dupuis L, Gaiddon C, et al. (2005). "Tissue specificity and regulation of the N-terminal diversity of reticulon 3". Biochem. J. 385 (Pt 1): 125–34. PMC 1134680 . PMID 15350194. doi:10.1042/BJ20040458.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Gan M, Qi Y, Wan Q, et al. (2005). "Mammalian apoptosis-inducing protein, HAP, induces bacterial cell death". Mol. Biol. Rep. 31 (3): 159–64. PMID 15560370. doi:10.1023/B:MOLE.0000043551.84883.c8.
Kuang E, Wan Q, Li X, et al. (2005). "ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP)". J. Cell. Physiol. 204 (2): 549–59. PMID 15799019. doi:10.1002/jcp.20340.
Cai Y, Saiyin H, Lin Q, et al. (2005). "Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain". Brain Res. Mol. Brain Res. 138 (2): 236–43. PMID 15946766. doi:10.1016/j.molbrainres.2005.04.020.
Wakana Y, Koyama S, Nakajima K, et al. (2005). "Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi". Biochem. Biophys. Res. Commun. 334 (4): 1198–205. PMID 16054885. doi:10.1016/j.bbrc.2005.07.012.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. PMID 16303743. doi:10.1093/dnares/12.2.117.
Heath JE, Siedlak SL, Zhu X, Lee HG, Thakur A, Yan R, Perry G, Smith MA, Castellani RJ (2010). "Widespread Distribution of Reticulon-3 in Various Neurodegenerative Diseases". Neuropathology. 30 (6): 574–9. PMC 2902651 . PMID 20374499. doi:10.1111/j.1440-1789.2010.01107.x.

External links

RTN3 human gene location in the UCSC Genome Browser.
RTN3 human gene details in the UCSC Genome Browser.

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RTN3

References

Further reading

External links