RSF1

Identifiers

RSF1, HBXAP, RSF-1, XAP8, p325, remodeling and spacing factor 1

External IDs

MGI: 2682305 HomoloGene: 41142 GeneCards: RSF1

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	No data available	Start	77,659,996 bp^[1]
Band	No data available	End	77,821,017 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	No data available	Start	97,579,889 bp^[2]
Band	No data available	End	97,692,778 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• histone binding • ATPase activity • protein binding • metal ion binding
Cellular component	• RSF complex • nucleus • nucleoplasm
Biological process	• positive regulation of transcription, DNA-templated • negative regulation of DNA binding • chromatin remodeling • positive regulation of viral transcription • nucleosome positioning • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • CENP-A containing nucleosome assembly • transcription, DNA-templated • DNA-templated transcription, initiation • nucleosome assembly • covalent chromatin modification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51773


233532

Ensembl


ENSG00000048649


ENSMUSG00000035623

UniProt


Q96T23 Q05DG0


n/a

RefSeq (mRNA)


NM_016578


NM_001081267

RefSeq (protein)


NP_057662 NP_057662.3


n/a

Location (UCSC)

Chr 11: 77.66 – 77.82 Mb

Chr 11: 97.58 – 97.69 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.^[5]^[6]^[7]

HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000048649 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035623 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y (Mar 2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". J Biol Chem. 277 (12): 9982–8. PMID 11788598. doi:10.1074/jbc.M111354200.
↑ Loyola A, Huang JY, LeRoy G, Hu S, Wang YH, Donnelly RJ, Lane WS, Lee SC, Reinberg D (Sep 2003). "Functional analysis of the subunits of the chromatin assembly factor RSF". Mol Cell Biol. 23 (19): 6759–68. PMC 193931 . PMID 12972596. doi:10.1128/MCB.23.19.6759-6768.2003.
1 2 "Entrez Gene: RSF1 remodeling and spacing factor 1".

Lee TH, Elledge SJ, Butel JS (1995). "Hepatitis B virus X protein interacts with a probable cellular DNA repair protein.". J. Virol. 69 (2): 1107–14. PMC 188683 . PMID 7815490.
LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro.". Science. 282 (5395): 1900–4. PMID 9836642. doi:10.1126/science.282.5395.1900.
Shamay M, Barak O, Shaul Y (2002). "HBXAP, a novel PHD-finger protein, possesses transcription repression activity.". Genomics. 79 (4): 523–9. PMID 11944984. doi:10.1006/geno.2002.6717.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells. 9 (2): 105–20. PMID 15009096. doi:10.1111/j.1365-2443.2004.00705.x.
Huang JY, Shen BJ, Tsai WH, Lee SC (2004). "Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB.". Exp. Cell Res. 298 (1): 133–43. PMID 15242768. doi:10.1016/j.yexcr.2004.04.019.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Shih IeM, Sheu JJ, Santillan A, et al. (2005). "Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma.". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 14004–9. PMC 1236547 . PMID 16172393. doi:10.1073/pnas.0504195102.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. PMID 16964243. doi:10.1038/nbt1240.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.

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RSF1

References

Further reading