40S ribosomal protein S14

RPS14

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC

Identifiers

Aliases

RPS14, EMTB, S14, ribosomal protein S14

External IDs

MGI: 98107 HomoloGene: 90926 GeneCards: RPS14

Gene ontology
Molecular function	• small ribosomal subunit rRNA binding • structural constituent of ribosome • translation regulator activity • protein binding • mRNA 5'-UTR binding • RNA binding
Cellular component	• cytosol • ribosome • membrane • focal adhesion • intracellular ribonucleoprotein complex • cytosolic small ribosomal subunit • nucleolus • Q39572 • extracellular exosome • extracellular matrix • nucleoplasm
Biological process	• maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • maturation of SSU-rRNA • viral transcription • negative regulation of transcription from RNA polymerase II promoter • SRP-dependent cotranslational protein targeting to membrane • translational initiation • erythrocyte differentiation • ribosomal small subunit assembly • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • rRNA processing • translation • regulation of translation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6208


20044

Ensembl


ENSG00000164587


ENSMUSG00000024608

UniProt


P62263


P62264

RefSeq (mRNA)


NM_005617 NM_001025070 NM_001025071


NM_020600

RefSeq (protein)


NP_001020241 NP_001020242 NP_005608


NP_065625

Location (UCSC)

Chr 5: 150.44 – 150.45 Mb

Chr 18: 60.77 – 60.78 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene.^[3]^[4]^[5]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor.^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Rhoads DD, Dixit A, Roufa DJ (Jan 1987). "Primary structure of human ribosomal protein S14 and the gene that encodes it". Mol Cell Biol. 6 (8): 2774–83. PMC 367844 . PMID 3785212.
↑ Diaz JJ, Roufa DJ (Apr 1992). "Fine-structure map of the human ribosomal protein gene RPS14". Mol Cell Biol. 12 (4): 1680–6. PMC 369611 . PMID 1549121.
1 2 "Entrez Gene: RPS14 ribosomal protein S14".

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. PMID 8722009. doi:10.1139/o95-101.
Chen IT, Dixit A, Rhoads DD, Roufa DJ (1986). "Homologous ribosomal proteins in bacteria, yeast, and humans.". Proc. Natl. Acad. Sci. U.S.A. 83 (18): 6907–11. PMC 386619 . PMID 3529092. doi:10.1073/pnas.83.18.6907.
Dana S, Wasmuth JJ (1983). "Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5.". Mol. Cell. Biol. 2 (10): 1220–8. PMC 369921 . PMID 7177110.
Tasheva ES, Roufa DJ (1995). "Regulation of human RPS14 transcription by intronic antisense RNAs and ribosomal protein S14.". Genes Dev. 9 (3): 304–16. PMID 7867928. doi:10.1101/gad.9.3.304.
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene. 146 (2): 199–207. PMID 8076819. doi:10.1016/0378-1119(94)90293-3.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry.". Eur. J. Biochem. 239 (1): 144–9. PMID 8706699. doi:10.1111/j.1432-1033.1996.0144u.x.
Martin-Nieto J, Roufa DJ (1997). "Functional analysis of human RPS14 null alleles.". J. Cell. Sci. 110 (8): 955–63. PMID 9152021.
Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes.". Genome Res. 8 (5): 509–23. PMID 9582194. doi:10.1101/gr.8.5.509.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438–46. PMC 2253395 . PMID 15883184. doi:10.1110/ps.041293005.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell. 125 (4): 801–14. PMID 16713569. doi:10.1016/j.cell.2006.03.032.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

Protein biosynthesis: translation (prokaryotic, eukaryotic)

Proteins

Initiation factor

Prokaryotic

Archaeal

aIF1
aIF2
aIF5
aIF6

Eukaryotic

eIF1	eIF1 EIF1AX AY 1B
eIF2	EIF2S1 EIF2S2 EIF2S3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF-2 kinase eIF2A eIF2D
eIF3	EIF3A B C D E F G H I J K L M
eIF4	EIF4A2 A3 B E1 E2 E3 G1 G2 G3 H
eIF5	EIF5 EIF5A A2 5B
eIF6	EIF6

Elongation factor

Prokaryotic	EF-Tu EF-Ts EF-G
Archaeal	aEF-1 aEF-2
Eukaryotic	EEF-1 EEF1A1 EEF1A2 EEF1A3 EEF1B1 EEF1B2 EEF1B3 EEF1B4 EEF1D EEF1E1 EEF1G EEF2

Release factor

Ribosomal Proteins

Cytoplasmic

60S subunit	RPL3 RPL4 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL10 RPL10A RPL10-like RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL16 RPL17 RPL18 RPL18A RPL19 RPL20 RPL21 RPL22 RPL23 RPL23A RPL24 RPL25 RPL26 RPL27 RPL27A RPL28 RPL29 RPL30 RPL31 RPL32 RPL33 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL40 RPL41 RPLP0 RPLP1 RPLP2 RPLP3 RRP15-like RSL24D1
40S subunit	RPSA RPS2 RPS3 RPS3A RPS4 (RPS4X, RPS4Y1, RPS4Y2) RPS5 RPS6 RPS7 RPS8 RPS9 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS20 RPS21 RPS22 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS30 RACK1

Mitochondrial

39S subunit	MRPL1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
28S subunit	MRPS1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

Other concepts

Ribosomal RNA / ribosome subunits

Prokaryotes (70S)

Large:
50S
5S
23S

Small:
30S
16S

Eukaryotes (80S)

Cytoplasmic	Large: 60S 5S 5.8S 28S Small: 40S 18S
Mitochondrial	MT-RNR1, 12S MT-RNR2, 16S

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40S ribosomal protein S14

References

Further reading