RNF19A

RNF19A
Identifiers
AliasesRNF19A, RNF19, ring finger protein 19A, RBR E3 ubiquitin protein ligase
External IDsMGI: 1353623 HomoloGene: 8501 GeneCards: RNF19A
Gene location (Human)
Chr.Chromosome 8 (human)[1]
BandNo data availableStart100,257,060 bp[1]
End100,336,218 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

25897

30945

Ensembl

ENSG00000034677

ENSMUSG00000022280

UniProt

Q9NV58

P50636

RefSeq (mRNA)

NM_001280539
NM_015435
NM_183419

NM_013923

RefSeq (protein)

NP_001267468
NP_056250
NP_904355

NP_038951

Location (UCSC)Chr 8: 100.26 – 100.34 MbChr 8: 36.24 – 36.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.[5][6][7]

The protein encoded by this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies (LBs), neuronal inclusions characteristic of Parkinson's disease (PD). This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript variants encoding the same protein have been reported.[7]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000034677 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022280 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G (Mar 2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem Biophys Res Commun. 281 (3): 706–13. PMID 11237715. doi:10.1006/bbrc.2001.4414.
  6. Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42. PMID 10976766. doi:10.1023/A:1007177623283.
  7. 1 2 "Entrez Gene: RNF19 ring finger protein 19".

Further reading


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