RNF123

RNF123

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2MA6

Identifiers

RNF123, KPC1, FP1477, ring finger protein 123

External IDs

MGI: 2148796 HomoloGene: 11112 GeneCards: RNF123

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	No data available	Start	49,689,499 bp^[1]
Band	No data available	End	49,721,529 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	No data available	Start	108,051,534 bp^[2]
Band	No data available	End	108,083,346 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• metal ion binding • transferase activity
Cellular component	• cytoplasm • cytosol
Biological process	• protein ubiquitination • protein deubiquitination
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


63891


84585


ENSG00000164068


ENSMUSG00000041528


Q5XPI4


Q5XPI3

RefSeq (mRNA)


NM_022064


NM_032543 NM_001311152

RefSeq (protein)


NP_071347


NP_001298081 NP_115932

Location (UCSC)

Chr 3: 49.69 – 49.72 Mb

Chr 3: 108.05 – 108.08 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene.^[5]

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.^[5]

See also

RING finger domain

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164068 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041528 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: RNF123 ring finger protein 123".

Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. PMC 524842 . PMID 15498874. doi:10.1073/pnas.0404089101.
Kamura T, Hara T, Matsumoto M, et al. (2005). "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.". Nat. Cell Biol. 6 (12): 1229–35. PMID 15531880. doi:10.1038/ncb1194.
Kotoshiba S, Kamura T, Hara T, et al. (2005). "Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase.". J. Biol. Chem. 280 (18): 17694–700. PMID 15746103. doi:10.1074/jbc.M500866200.
Hara T, Kamura T, Kotoshiba S, et al. (2005). "Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle.". Mol. Cell. Biol. 25 (21): 9292–303. PMC 1265808 . PMID 16227581. doi:10.1128/MCB.25.21.9292-9303.2005.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

External links

RNF123 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

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