RINT1

RINT1

Identifiers

RINT1, RINT-1, RAD50 interactor 1

External IDs

MGI: 1916233 HomoloGene: 11070 GeneCards: RINT1

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	No data available	Start	105,532,085 bp^[1]
Band	No data available	End	105,567,677 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	No data available	Start	23,787,711 bp^[2]
Band	No data available	End	23,820,369 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding
Cellular component	• cytoplasm • Dsl1/NZR complex • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • cytosol
Biological process	• protein transport • cell cycle • regulation of signal transduction involved in mitotic G2 DNA damage checkpoint • regulation of ER to Golgi vesicle-mediated transport • Golgi vesicle transport • vesicle-mediated transport • retrograde vesicle-mediated transport, Golgi to ER • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


60561


72772


ENSG00000135249


ENSMUSG00000028999


Q6NUQ1


Q8BZ36

RefSeq (mRNA)


NM_021930 NM_001346599 NM_001346600 NM_001346601 NM_001346603


NM_177323 NM_001310467

RefSeq (protein)


NP_001333528 NP_001333529 NP_001333530 NP_001333532 NP_068749


NP_001297396 NP_796297

Location (UCSC)

Chr 7: 105.53 – 105.57 Mb

Chr 7: 23.79 – 23.82 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

RAD50-interacting protein 1 is a protein that in humans is encoded by the RINT1 gene.^[5]^[6]^[7]

Interactions

RINT1 has been shown to interact with Rad50^[5] and ZW10.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135249 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028999 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 Xiao J, Liu CC, Chen PL, Lee WH (Mar 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". J Biol Chem. 276 (9): 6105–11. PMID 11096100. doi:10.1074/jbc.M008893200.
1 2 Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. PMC 381410 . PMID 15029241. doi:10.1038/sj.emboj.7600135.
↑ "Entrez Gene: RINT1 RAD50 interactor 1".

Further reading

"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074. doi:10.1101/gr.8.11.1097.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Nakajima K, Hirose H, Taniguchi M, et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. PMC 514507 . PMID 15272311. doi:10.1038/sj.emboj.7600333.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Arasaki K, Taniguchi M, Tani K, Tagaya M (2006). "RINT-1 Regulates the Localization and Entry of ZW10 to the Syntaxin 18 Complex". Mol. Biol. Cell. 17 (6): 2780–8. PMC 1474792 . PMID 16571679. doi:10.1091/mbc.E05-10-0973.
Kong LJ, Meloni AR, Nevins JR (2006). "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1". Mol. Cell. 22 (1): 63–71. PMID 16600870. doi:10.1016/j.molcel.2006.02.016.
Lin X, Liu CC, Gao Q, et al. (2007). "RINT-1 Serves as a Tumor Suppressor and Maintains Golgi Dynamics and Centrosome Integrity for Cell Survival". Mol. Cell. Biol. 27 (13): 4905–16. PMC 1951495 . PMID 17470549. doi:10.1128/MCB.02396-06.
Sun Y, Shestakova A, Hunt L, et al. (2007). "Rab6 Regulates Both ZW10/RINT-1– and Conserved Oligomeric Golgi Complex-dependent Golgi Trafficking and Homeostasis". Mol. Biol. Cell. 18 (10): 4129–42. PMC 1995728 . PMID 17699596. doi:10.1091/mbc.E07-01-0080.

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