RGS5
| RGS5 |
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| Identifiers |
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| Aliases | RGS5, MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129, regulator of G-protein signaling 5 |
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| External IDs | MGI: 1098434 HomoloGene: 2682 GeneCards: RGS5 |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 1 (mouse)[1] |
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| | Band | No data available | Start | 169,655,501 bp[1] |
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| End | 169,695,813 bp[1] |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | n/a | Chr 1: 169.66 – 169.7 Mb |
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| PubMed search | [2] | [3] |
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| Wikidata |
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Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene.[4][5]
The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators.[supplied by OMIM][5]
Interactions
RGS5 has been shown to interact with GNAO1,[6][7] GNAI2[6][7] and GNAI3.[6][7]
References
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026678 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T (October 1998). "Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene". J Hum Genet. 43 (3): 202–5. PMID 9747037. doi:10.1007/s100380050071.
- 1 2 "Entrez Gene: RGS5 regulator of G-protein signalling 5".
- 1 2 3 Chen, C; Zheng B; Han J; Lin S C (March 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. UNITED STATES. 272 (13): 8679–85. ISSN 0021-9258. PMID 9079700. doi:10.1074/jbc.272.13.8679.
- 1 2 3 Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (February 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. England. 68 (13): 1457–69. ISSN 0024-3205. PMID 11253162. doi:10.1016/S0024-3205(01)00939-0.
Further reading
- Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. 272 (13): 8679–85. PMID 9079700. doi:10.1074/jbc.272.13.8679.
- Cismowski MJ, Takesono A, Ma C, et al. (1999). "Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling". Nat. Biotechnol. 17 (9): 878–83. PMID 10471929. doi:10.1038/12867.
- Adams LD, Geary RL, McManus B, Schwartz SM (2000). "A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media". Circ. Res. 87 (7): 623–31. PMID 11009569. doi:10.1161/01.res.87.7.623.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. PMC 310948
. PMID 11076863. doi:10.1101/gr.143000.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
- Zhou J, Moroi K, Nishiyama M, et al. (2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. 68 (13): 1457–69. PMID 11253162. doi:10.1016/S0024-3205(01)00939-0.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Morris DW, Rodgers A, McGhee KA, et al. (2005). "Confirming RGS4 as a susceptibility gene for schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 125 (1): 50–3. PMID 14755443. doi:10.1002/ajmg.b.20109.
- Berger M, Bergers G, Arnold B, et al. (2005). "Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization". Blood. 105 (3): 1094–101. PMID 15459006. doi:10.1182/blood-2004-06-2315.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
- Liang Y, Li C, Guzman VM, et al. (2005). "Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues". FEBS J. 272 (3): 791–9. PMID 15670159. doi:10.1111/j.1742-4658.2004.04516.x.
- Adams LD, Geary RL, Li J, et al. (2006). "Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap". Arterioscler. Thromb. Vasc. Biol. 26 (2): 319–25. PMID 16293795. doi:10.1161/01.ATV.0000196647.45718.d6.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.
- Rhee KH, Nam KH, Lee WH, et al. (2007). "Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-". Protein Pept. Lett. 13 (9): 945–9. PMID 17100651. doi:10.2174/092986606778256225.
- Bodenstein J, Sunahara RK, Neubig RR (2007). "N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells". Mol. Pharmacol. 71 (4): 1040–50. PMID 17220356. doi:10.1124/mol.106.029397.
- Yang Z, Gaudio S, Song W, et al. (2007). "Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5)". Cell. Physiol. Biochem. 20 (5): 303–10. PMID 17762159. doi:10.1159/000107516.
PDB gallery |
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| 2crp: Solution structure of the RGS domain of regulator of G-protein signalling 5 (RGS 5) |
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