RGS1
Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.[5][6][7]
This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.[7]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000090104 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026358 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Newton JS, Deed RW, Mitchell EL, Murphy JJ, Norton JD (Jan 1994). "A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein". Biochim Biophys Acta. 1216 (2): 314–6. PMID 8241276. doi:10.1016/0167-4781(93)90163-8.
- ↑ Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–6. PMID 8602223. doi:10.1038/379742a0.
- 1 2 "Entrez Gene: RGS1 regulator of G-protein signalling 1".
Further reading
- Hong JX, Wilson GL, Fox CH, Kehrl JH (1993). "Isolation and characterization of a novel B cell activation gene.". J. Immunol. 150 (9): 3895–904. PMID 8473738.
- Heximer SP, Cristillo AD, Forsdyke DR (1997). "Comparison of mRNA expression of two regulators of G-protein signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood mononuclear cells.". DNA Cell Biol. 16 (5): 589–98. PMID 9174164. doi:10.1089/dna.1997.16.589.
- Bowman EP, Campbell JJ, Druey KM, et al. (1998). "Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members.". J. Biol. Chem. 273 (43): 28040–8. PMID 9774420. doi:10.1074/jbc.273.43.28040.
- Denecke B, Meyerdierks A, Böttger EC (1999). "RGS1 is expressed in monocytes and acts as a GTPase-activating protein for G-protein-coupled chemoattractant receptors.". J. Biol. Chem. 274 (38): 26860–8. PMID 10480894. doi:10.1074/jbc.274.38.26860.
- Popov SG, Krishna UM, Falck JR, Wilkie TM (2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.". J. Biol. Chem. 275 (25): 18962–8. PMID 10747990. doi:10.1074/jbc.M001128200.
- Zheng B, Chen D, Farquhar MG (2000). "MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3999–4004. PMC 18131 . PMID 10760272. doi:10.1073/pnas.97.8.3999.
- Lou X, Yano H, Lee F, et al. (2001). "GIPC and GAIP Form a Complex with TrkA: A Putative Link between G Protein and Receptor Tyrosine Kinase Pathways". Mol. Biol. Cell. 12 (3): 615–27. PMC 30968 . PMID 11251075. doi:10.1091/mbc.12.3.615.
- Hoffmann M, Ward RJ, Cavalli A, et al. (2001). "Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha". J. Neurochem. 78 (4): 797–806. PMID 11520900. doi:10.1046/j.1471-4159.2001.00479.x.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Le Y, Honczarenko M, Glodek AM, et al. (2005). "CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells". J. Immunol. 174 (5): 2582–90. PMID 15728464. doi:10.4049/jimmunol.174.5.2582.
- Han JI, Huang NN, Kim DU, Kehrl JH (2006). "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization". J. Leukoc. Biol. 79 (6): 1357–68. PMID 16565322. doi:10.1189/jlb.1105693.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.
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