RFFL

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1Y02

Identifiers

Aliases

RFFL, CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L, ring finger and FYVE-like domain containing E3 ubiquitin protein ligase, ring finger and FYVE like domain containing E3 ubiquitin protein ligase

External IDs

MGI: 1914588 HomoloGene: 12116 GeneCards: RFFL

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	No data available	Start	35,005,990 bp^[1]
Band	No data available	End	35,089,319 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	No data available	Start	82,802,449 bp^[2]
Band	No data available	End	82,871,210 bp^[2]

Gene ontology
Molecular function	• p53 binding • metal ion binding • protease binding • protein binding • protein kinase binding • ubiquitin protein ligase binding • ubiquitin protein ligase activity • transferase activity
Cellular component	• cytoplasm • cytosol • endosome • membrane • plasma membrane • Golgi membrane • tumor necrosis factor receptor superfamily complex • recycling endosome membrane • lysosome • endosome membrane • nucleoplasm
Biological process	• regulation of TOR signaling • ubiquitin-dependent protein catabolic process • negative regulation of tumor necrosis factor-mediated signaling pathway • protein K48-linked ubiquitination • negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • protein ubiquitination • negative regulation of signal transduction by p53 class mediator • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • regulation of fibroblast migration • proteasome-mediated ubiquitin-dependent protein catabolic process • apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


117584


67338

Ensembl


ENSG00000092871


ENSMUSG00000020696

UniProt


Q8WZ73


Q6ZQM0

RefSeq (mRNA)


NM_001017368 NM_057178


NM_001007465 NM_001164569 NM_001164570 NM_001164571 NM_026097

RefSeq (protein)


NP_001017368


NP_001007466 NP_001158041 NP_001158042 NP_001158043 NP_080373

Location (UCSC)

Chr 17: 35.01 – 35.09 Mb

Chr 17: 82.8 – 82.87 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

E3 ubiquitin-protein ligase rififylin is an enzyme that in humans is encoded by the RFFL gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000092871 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020696 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Coumailleau F, Das V, Alcover A, Raposo G, Vandormael-Pournin S, Le Bras S, Baldacci P, Dautry-Varsat A, Babinet C, Cohen-Tannoudji M (Sep 2004). "Over-Expression of Rififylin, a New RING Finger and FYVE-like Domain-containing Protein, Inhibits Recycling from the Endocytic Recycling Compartment". Mol Biol Cell. 15 (10): 4444–56. PMC 519139 . PMID 15229288. doi:10.1091/mbc.E04-04-0274.
↑ "Entrez Gene: RFFL ring finger and FYVE-like domain containing 1".

RFFL

References

Further reading