RENBP

Identifiers

RENBP, RBP, RNBP, renin binding protein

External IDs

MGI: 105940 HomoloGene: 2184 GeneCards: RENBP

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	No data available	Start	153,935,263 bp^[1]
Band	No data available	End	153,944,691 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	No data available	Start	73,922,121 bp^[2]
Band	No data available	End	73,930,850 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• enzyme inhibitor activity • endopeptidase inhibitor activity • catalytic activity • isomerase activity • ATP binding • protein homodimerization activity • purine nucleotide binding • N-acylglucosamine 2-epimerase activity
Cellular component	• extracellular exosome • cytosol
Biological process	• N-acetylmannosamine metabolic process • regulation of blood pressure • N-acetylneuraminate catabolic process • negative regulation of catalytic activity • negative regulation of endopeptidase activity • N-acetylglucosamine metabolic process • UDP-N-acetylglucosamine biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5973


19703

Ensembl


ENSG00000102032


ENSMUSG00000031387

UniProt


P51606


P82343

RefSeq (mRNA)


NM_002910


NM_001164704 NM_023132

RefSeq (protein)


NP_002901


NP_001158176 NP_075621

Location (UCSC)

Chr X: 153.94 – 153.94 Mb

Chr X: 73.92 – 73.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

N-acylglucosamine 2-epimerase is an enzyme that in humans is encoded by the RENBP gene.^[5]^[6]

The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102032 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031387 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Takahashi S, Inoue H, Miyake Y (Aug 1992). "The human gene for renin-binding protein". J Biol Chem. 267 (18): 13007–13. PMID 1618798.
1 2 "Entrez Gene: RENBP renin binding protein".

Inoue H, Takahashi S, Fukui K, Miyake Y (1992). "Genetic and molecular properties of human and rat renin-binding proteins with reference to the function of the leucine zipper motif". J. Biochem. 110 (4): 493–500. PMID 1723410.
Takahashi S, Miura R, Miyake Y (1985). "A study on renin binding protein (RnBP) in the human kidney". J. Biochem. 97 (2): 671–7. PMID 3924907.
Murakami K, Hirose S, Chino S, et al. (1983). "Properties of renin-binding protein". Clinical and experimental hypertension. Part A, Theory and practice. 4 (11–12): 2073–81. PMID 6756682. doi:10.3109/10641968209062372.
Faranda S, Frattini A, Vezzoni P (1995). "The human genes encoding renin-binding protein and host cell factor are closely linked in Xq28 and transcribed in the same direction". Gene. 155 (2): 237–9. PMID 7721097. doi:10.1016/0378-1119(94)00810-F.
van den Ouweland AM, Verdijk M, Kiochis P, et al. (1994). "The human renin-binding protein gene (RENBP) maps in Xq28". Genomics. 21 (1): 279–81. PMID 8088804. doi:10.1006/geno.1994.1259.
Knöll A, Schunkert H, Reichwald K, et al. (1998). "Human renin binding protein: complete genomic sequence and association of an intronic T/C polymorphism with the prorenin level in males". Hum. Mol. Genet. 6 (9): 1527–34. PMID 9285790. doi:10.1093/hmg/6.9.1527.
Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. PMID 9286695. doi:10.1006/geno.1997.4822.
Stäsche R, Hinderlich S, Weise C, et al. (1997). "A bifunctional enzyme catalyzes the first two steps in N-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-N-acetyl-glucosamine 2-epimerase/N-acetylmannosamine kinase". J. Biol. Chem. 272 (39): 24319–24. PMID 9305888. doi:10.1074/jbc.272.39.24319.
Takahashi S, Takahashi K, Kaneko T, et al. (1999). "Human renin-binding protein is the enzyme N-acetyl-D-glucosamine 2-epimerase". J. Biochem. 125 (2): 348–53. PMID 9990133. doi:10.1093/oxfordjournals.jbchem.a022293.
Takahashi S, Kumagai M, Shindo S, et al. (2001). "Renin inhibits N-acetyl-D-glucosamine 2-epimerase (renin-binding protein)". J. Biochem. 128 (6): 951–6. PMID 11098137. doi:10.1093/oxfordjournals.jbchem.a022846.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
Lapteva N, Nieda M, Ando Y, et al. (2001). "Expression of renin-angiotensin system genes in immature and mature dendritic cells identified using human cDNA microarray". Biochem. Biophys. Res. Commun. 285 (4): 1059–65. PMID 11467860. doi:10.1006/bbrc.2001.5215.
Takahashi S, Ogasawara H, Takahashi K, et al. (2002). "Identification of a domain conferring nucleotide binding to the N-acetyl-d-glucosamine 2-epimerase (Renin binding protein)". J. Biochem. 131 (4): 605–10. PMID 11926999. doi:10.1093/oxfordjournals.jbchem.a003140.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi CR (2003). "GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism". J. Biol. Chem. 278 (10): 8035–42. PMID 12499362. doi:10.1074/jbc.M212127200.
Bohlmeyer T, Ferdensi A, Bristow MR, et al. (2003). "Selective activation of N-acyl-D-glucosamine 2-epimerase expression in failing human heart ventricular myocytes". J. Card. Fail. 9 (1): 59–68. PMID 12612874. doi:10.1054/jcaf.2003.6.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.

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RENBP

References

Further reading