LMO2

LMO2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLMO2, RBTN2, RBTNL1, RHOM2, TTG2, LIM domain only 2
External IDsMGI: 102811 HomoloGene: 4072 GeneCards: LMO2
Gene location (Human)
Chr.Chromosome 11 (human)[1]
BandNo data availableStart33,858,576 bp[1]
End33,892,289 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

4005

16909

Ensembl

ENSG00000135363

ENSMUSG00000032698

UniProt

P25791

P25801

RefSeq (mRNA)

NM_001142315
NM_001142316
NM_005574

NM_001142335
NM_001142336
NM_001142337
NM_008505

RefSeq (protein)

NP_001135787
NP_001135788
NP_005565

NP_001135807
NP_001135808
NP_001135809
NP_032531

Location (UCSC)Chr 11: 33.86 – 33.89 MbChr 11: 103.96 – 103.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LIM domain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2. LMO2 is a protein which in humans is encoded by the LMO2 gene.[5]

Function

LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropoiesis.[6] The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved.

Clinical significance

The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number of T-cell acute lymphoblastic leukemia-specific translocations occur.[7]

Interactions

LMO2 has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000135363 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032698 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (May 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13". Proceedings of the National Academy of Sciences of the United States of America. 88 (10): 4367–71. PMC 51660Freely accessible. PMID 2034676. doi:10.1073/pnas.88.10.4367.
  6. Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH (Jul 1994). "The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development". Cell. 78 (1): 45–57. PMID 8033210. doi:10.1016/0092-8674(94)90571-1.
  7. EntrezGene 4005
  8. 1 2 3 Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (Oct 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proceedings of the National Academy of Sciences of the United States of America. 92 (21): 9585–9. PMC 40846Freely accessible. PMID 7568177. doi:10.1073/pnas.92.21.9585.
  9. Mao S, Neale GA, Goorha RM (Apr 1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2". Oncogene. 14 (13): 1531–9. PMID 9129143. doi:10.1038/sj.onc.1200988.
  10. Bégay-Müller V, Ansieau S, Leutz A (Jun 2002). "The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene". FEBS Letters. 521 (1-3): 36–8. PMID 12067721. doi:10.1016/s0014-5793(02)02814-4.
  11. Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (Oct 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". The EMBO Journal. 13 (20): 4831–9. PMC 395422Freely accessible. PMID 7957052.
  12. Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (Aug 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proceedings of the National Academy of Sciences of the United States of America. 91 (18): 8617–21. PMC 44657Freely accessible. PMID 8078932. doi:10.1073/pnas.91.18.8617.
  13. Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (Jan 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". The EMBO Journal. 25 (2): 357–66. PMC 1383517Freely accessible. PMID 16407974. doi:10.1038/sj.emboj.7600934.

Further reading

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