RBPJ

RBPJ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2F8X, 3NBN, 3V79
Identifiers
Aliases	RBPJ, AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region
External IDs	MGI: 96522 HomoloGene: 7511 GeneCards: RBPJ
Gene location (Human) Chr. Chromosome 4 (human)[1] Band No data available Start 26,163,455 bp[1] End 26,435,131 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band No data available Start 53,466,152 bp[2] End 53,657,362 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein N-terminus binding • RNA polymerase II repressing transcription factor binding • protein binding • RNA polymerase II core promoter sequence-specific DNA binding • recombinase activity • chromatin binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • repressing transcription factor binding Cellular component • nucleolus • MAML1-RBP-Jkappa- ICN1 complex • transcription factor complex • cytoplasm • nucleus • nucleoplasm • transcriptional repressor complex Biological process • artery morphogenesis • regulation of transcription from RNA polymerase II promoter • neuron differentiation • epidermal cell fate specification • positive regulation of cell proliferation • Clara cell differentiation • interleukin-4 secretion • somatic stem cell population maintenance • endocardium development • cell fate commitment • DNA recombination • somitogenesis • hemopoiesis • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • defense response to bacterium • regulation of timing of cell differentiation • regulation of transcription, DNA-templated • humoral immune response • keratinocyte differentiation • hair follicle maturation • negative regulation of cell proliferation • pituitary gland development • negative regulation of cell differentiation • Notch signaling involved in heart development • transcription, DNA-templated • positive regulation of gene expression • arterial endothelial cell fate commitment • myeloid dendritic cell differentiation • blood vessel remodeling • secondary heart field specification • regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • sebaceous gland development • positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment • inflammatory response to antigenic stimulus • heart development • auditory receptor cell fate commitment • B cell differentiation • regulation of gene expression • Notch signaling pathway • dorsal aorta morphogenesis • atrioventricular canal development • positive regulation of ephrin receptor signaling pathway • epithelial to mesenchymal transition involved in endocardial cushion formation • outflow tract morphogenesis • cardiac left ventricle morphogenesis • negative regulation of transcription from RNA polymerase II promoter • labyrinthine layer blood vessel development • blood vessel lumenization • endocardium morphogenesis • ventricular trabecula myocardium morphogenesis • negative regulation of ossification • positive regulation of cell proliferation involved in heart morphogenesis • regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation • positive regulation of cardiac muscle cell proliferation • positive regulation of transcription of Notch receptor target • angiogenesis • epithelial to mesenchymal transition • positive regulation of BMP signaling pathway • positive regulation of ERBB signaling pathway • blood vessel endothelial cell fate specification • negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3516	19664
Ensembl	ENSG00000168214	ENSMUSG00000039191
UniProt	Q06330	P31266
RefSeq (mRNA)	NM_005349 NM_015874 NM_203283 NM_203284	NM_001080927 NM_001080928 NM_001277116 NM_009035
RefSeq (protein)	NP_005340 NP_056958 NP_976028 NP_976029	NP_001074396 NP_001074397 NP_001264045 NP_033061
Location (UCSC)	Chr 4: 26.16 – 26.44 Mb	Chr 4: 53.47 – 53.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Recombining binding protein suppressor of hairless is a protein that in humans is encoded by the RBPJ gene.^[5][6][7]

RBPJ^[8] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.^[9]

Interactions

RBPJ has been shown to interact with:

• NOTCH1^[10][11]
• NCOR2,^[12][13]
• PCAF,^[14]
• SND1,^[15][16] and
• SNW1.^[15][17]

References

Further reading

External links

• RBPJ protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.