RBM9

RBFOX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQ3
Identifiers
Aliases	RBFOX2, FOX2, Fox-2, HNRBP2, HRNBP2, RBM9, RTA, dJ106I20.3, fxh, RNA binding protein, fox-1 homolog 2
External IDs	MGI: 1933973 HomoloGene: 49375 GeneCards: RBFOX2
Gene location (Human) Chr. Chromosome 22 (human)[1] Band No data available Start 35,738,736 bp[1] End 36,028,425 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band No data available Start 77,078,990 bp[2] End 77,307,053 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transcription corepressor activity • transcription factor binding • protein binding • RNA binding • nucleic acid binding • mRNA binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol Biological process • neuromuscular process controlling balance • dendrite morphogenesis • mRNA processing • regulation of alternative mRNA splicing, via spliceosome • nervous system development • regulation of RNA splicing • regulation of cell proliferation • RNA splicing • radial glia guided migration of Purkinje cell • regulation of definitive erythrocyte differentiation • RNA metabolic process • negative regulation of transcription, DNA-templated • intracellular estrogen receptor signaling pathway • fibroblast growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23543	93686
Ensembl	ENSG00000277564 ENSG00000100320	ENSMUSG00000033565
UniProt	O43251	Q8BP71
RefSeq (mRNA)	NM_001031695 NM_001082576 NM_001082577 NM_001082578 NM_001082579 NM_014309 NM_001349982 NM_001349983 NM_001349989 NM_001349990 NM_001349991 NM_001349992 NM_001349994 NM_001349995 NM_001349996 NM_001349997 NM_001349998 NM_001349999	NM_001110827 NM_001110828 NM_001110829 NM_001110830 NM_001286417 NM_001286418 NM_001286419 NM_053104 NM_175387
RefSeq (protein)	NP_001026865 NP_001076045 NP_001076046 NP_001076047 NP_001076048 NP_055124 NP_001336911 NP_001336912 NP_001336918 NP_001336919 NP_001336920 NP_001336921 NP_001336923 NP_001336924 NP_001336925 NP_001336926 NP_001336927 NP_001336928	NP_001104297 NP_001104298 NP_001104299 NP_001104300 NP_001273346 NP_001273347 NP_001273348 NP_444334 NP_780596
Location (UCSC)	Chr 22: 35.74 – 36.03 Mb	Chr 22: 77.08 – 77.31 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

RNA binding motif protein 9, also known as RBM9 or FOX-2, is a protein which in humans is encoded by the RBM9 gene.^[5]

Function

RBM9 is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene.^[5]

RBM9, as determined by CLIP-seq, binds near alternatively spliced exons and regulates the inclusion or exclusion of exons during alternative splicing by binding in introns either downstream (inclusion) or upstream (exon skipping) of exons. Its presence is important for stem cell survival and knockdowns of RBM9 activate markers for apoptosis.^[6]

References

Further reading