RASSF2

Identifiers

RASSF2, CENP-34, RASFADIN, Ras association domain family member 2

External IDs

MGI: 2442060 HomoloGene: 22840 GeneCards: RASSF2

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	No data available	Start	4,780,023 bp^[1]
Band	No data available	End	4,823,645 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	No data available	Start	131,989,415 bp^[2]
Band	No data available	End	132,030,258 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding • protein kinase activity
Cellular component	• protein complex • cytoplasm • nucleus • chromosome, centromeric region • condensed chromosome kinetochore • kinetochore • chromosome • nucleoplasm • Golgi apparatus • cytosol
Biological process	• positive regulation of JNK cascade • positive regulation of protein autophosphorylation • skeletal system development • regulation of osteoclast differentiation • negative regulation of peptidyl-serine phosphorylation • regulation of osteoblast differentiation • regulation of NIK/NF-kappaB signaling • homeostasis of number of cells • bone remodeling • ossification • negative regulation of NIK/NF-kappaB signaling • epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade • positive regulation of apoptotic process • signal transduction • positive regulation of protein kinase activity • protein stabilization • cell cycle • protein phosphorylation • regulation of apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9770


215653

Ensembl


ENSG00000101265


ENSMUSG00000027339

UniProt


P50749


Q8BMS9

RefSeq (mRNA)


NM_014737 NM_170774


NM_175445

RefSeq (protein)


NP_055552 NP_739580


NP_780654

Location (UCSC)

Chr 20: 4.78 – 4.82 Mb

Chr 20: 131.99 – 132.03 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.^[5]^[6]^[7]

This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported.^[7]

Interactions

RASSF2 has been shown to interact with KRAS.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101265 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027339 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. PMID 8724849. doi:10.1093/dnares/3.1.17.
↑ Hesson LB, Wilson R, Morton D, Adams C, Walker M, Maher ER, Latif F (Jun 2005). "CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations". Oncogene. 24 (24): 3987–94. PMID 15806169. doi:10.1038/sj.onc.1208566.
1 2 "Entrez Gene: RASSF2 Ras association (RalGDS/AF-6) domain family 2".
↑ Vos, Michele D; Ellis Chad A; Elam Candice; Ulku Aylin S; Taylor Barbara J; Clark Geoffrey J (Jul 2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. United States. 278 (30): 28045–51. ISSN 0021-9258. PMID 12732644. doi:10.1074/jbc.M300554200.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Comincini S, Castiglioni BM, Foti GM, et al. (2001). "Isolation and molecular characterization of rasfadin, a novel gene in the vicinity of the bovine prion gene". Mamm. Genome. 12 (2): 150–6. PMID 11210185. doi:10.1007/s003350010239.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. PMID 11780052. doi:10.1038/414865a.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Vos MD, Ellis CA, Elam C, et al. (2003). "RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor". J. Biol. Chem. 278 (30): 28045–51. PMID 12732644. doi:10.1074/jbc.M300554200.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Fujita H, Fukuhara S, Sakurai A, et al. (2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes". J. Biol. Chem. 280 (6): 5022–31. PMID 15569673. doi:10.1074/jbc.M409701200.
Akino K, Toyota M, Suzuki H, et al. (2005). "The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer". Gastroenterology. 129 (1): 156–69. PMID 16012945. doi:10.1053/j.gastro.2005.03.051.
Endoh M, Tamura G, Honda T, et al. (2006). "RASSF2, a potential tumour suppressor, is silenced by CpG island hypermethylation in gastric cancer". Br. J. Cancer. 93 (12): 1395–9. PMC 2361541 . PMID 16265349. doi:10.1038/sj.bjc.6602854.
Zhang Z, Sun D, Van do N, et al. (2007). "Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma". Int. J. Cancer. 120 (1): 32–8. PMID 17013896. doi:10.1002/ijc.22185.
Park HW, Kang HC, Kim IJ, et al. (2007). "Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers". Int. J. Cancer. 120 (1): 7–12. PMID 17013898. doi:10.1002/ijc.22276.
Kumari G, Singhal PK, Rao MR, Mahalingam S (2007). "Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals". J. Mol. Biol. 367 (5): 1294–311. PMID 17320110. doi:10.1016/j.jmb.2007.01.026.
Kaira K, Sunaga N, Tomizawa Y, et al. (2007). "Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers". Int. J. Oncol. 31 (1): 169–73. PMID 17549418. doi:10.3892/ijo.31.1.169.

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RASSF2

Interactions

References

Further reading