RAP1GDS1

RAP1GDS1
Identifiers
AliasesRAP1GDS1, GDS1, SmgGDS, Rap1 GTPase-GDP dissociation stimulator 1
External IDsMGI: 2385189 HomoloGene: 41422 GeneCards: RAP1GDS1
Gene location (Human)
Chr.Chromosome 4 (human)[1]
BandNo data availableStart98,261,384 bp[1]
End98,443,861 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5910

229877

Ensembl

ENSG00000138698

ENSMUSG00000028149

UniProt

P52306

n/a

RefSeq (mRNA)

NM_001040690
NM_001286759
NM_145544

RefSeq (protein)

n/a

Location (UCSC)Chr 4: 98.26 – 98.44 MbChr 4: 138.93 – 139.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.[5][6][7]

Interactions

RAP1GDS1 has been shown to interact with KIFAP3,[8] HRAS[9] and RHOA.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000138698 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028149 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet. 92 (6): 629–30. PMID 8262526. doi:10.1007/BF00420952.
  6. ↑ Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem. 283 (2): 963–76. PMID 17951244. doi:10.1074/jbc.M707526200.
  7. ↑ "Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1".
  8. ↑ Shimizu, K; Kawabe H; Minami S; Honda T; Takaishi K; Shirataki H; Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. UNITED STATES. 271 (43): 27013–7. ISSN 0021-9258. PMID 8900189. doi:10.1074/jbc.271.43.27013.
  9. 1 2 Vikis, Haris G; Stewart Scott; Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. England. 21 (15): 2425–32. ISSN 0950-9232. PMID 11948427. doi:10.1038/sj.onc.1205306.

Further reading

  • Kikuchi A, Kaibuchi K, Hori Y, et al. (1992). "Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21.". Oncogene. 7 (2): 289–93. PMID 1549351. 
  • Shimizu K, Kawabe H, Minami S, et al. (1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase.". J. Biol. Chem. 271 (43): 27013–7. PMID 8900189. doi:10.1074/jbc.271.43.27013. 
  • Vikis HG, Stewart S, Guan KL (2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms.". Oncogene. 21 (15): 2425–32. PMID 11948427. doi:10.1038/sj.onc.1205306. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 Freely accessible. PMID 12477932. doi:10.1073/pnas.242603899. 
  • de Bruyn KM, Zwartkruis FJ, de Rooij J, et al. (2003). "The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes.". J. Biol. Chem. 278 (25): 22412–7. PMID 12690117. doi:10.1074/jbc.M212036200. 
  • Tiwari S, Felekkis K, Moon EY, et al. (2004). "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.". Blood. 103 (7): 2661–7. PMID 14615375. doi:10.1182/blood-2003-06-2154. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 


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