RAP1GAP2

RAP1GAP2
Identifiers
AliasesRAP1GAP2, GARNL4, RAP1GA3, RAP1 GTPase activating protein 2
External IDsMGI: 3028623 HomoloGene: 56695 GeneCards: RAP1GAP2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
BandNo data availableStart2,755,705 bp[1]
End3,037,739 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23108

380711

Ensembl

ENSG00000132359

ENSMUSG00000038807

UniProt

Q684P5

Q5SVL6

RefSeq (mRNA)

NM_001100398
NM_015085
NM_001330058

NM_001015046

RefSeq (protein)

NP_001093868
NP_001316987
NP_055900

NP_001015046

Location (UCSC)Chr 17: 2.76 – 3.04 MbChr 17: 74.38 – 74.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene. [5]

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000132359 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038807 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: RAP1 GTPase activating protein 2". Retrieved 2012-04-20.

Further reading

  • Neumuller, O.; Hoffmeister, M.; Babica, J.; Prelle, C.; Gegenbauer, K.; Smolenski, A. P. (2009). "Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets". Blood. 114 (7): 1396–1404. PMID 19528539. doi:10.1182/blood-2008-05-155234. 
  • Aouizerat, B. E.; Vittinghoff, E.; Musone, S. L.; Pawlikowska, L.; Kwok, P. Y.; Olgin, J. E.; Tseng, Z. H. (2011). "GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease". BMC Cardiovascular Disorders. 11: 29. PMC 3141757 Freely accessible. PMID 21658281. doi:10.1186/1471-2261-11-29. 
  • Balduini, A.; Pecci, A.; Lova, P.; Arezzi, N.; Marseglia, C.; Bellora, F.; Perotti, C.; Balduini, C.; Balduini, C. L.; Torti, M. (2004). "Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes". Experimental Cell Research. 300 (1): 84–93. PMID 15383317. doi:10.1016/j.yexcr.2004.07.011. 
  • Kimura, T.; Mogi, C.; Sato, K.; Tomura, H.; Ohta, H.; Im, D. -S.; Kuwabara, A.; Kurose, H.; Murakami, M.; Okajima, F. (2011). "P2y5/LPA6 attenuates LPA1-mediated VE-cadherin translocation and cell-cell dissociation through G12/13 protein-Src-Rap1". Cardiovascular Research. 92 (1): 149–158. PMID 21632882. doi:10.1093/cvr/cvr154. 
  • Schultess, J.; Danielewski, O.; Smolenski, A. P. (2005). "Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets". Blood. 105 (8): 3185–3192. PMID 15632203. doi:10.1182/blood-2004-09-3605. 
  • Hoffmeister, M.; Riha, P.; Neumuller, O.; Danielewski, O.; Schultess, J.; Smolenski, A. P. (2007). "Cyclic Nucleotide-dependent Protein Kinases Inhibit Binding of 14-3-3 to the GTPase-activating Protein Rap1GAP2 in Platelets". Journal of Biological Chemistry. 283 (4): 2297–2306. PMID 18039662. doi:10.1074/jbc.M706825200. 


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