RALGDS

RALGDS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRALGDS, RGDS, RGF, RalGEF, ral guanine nucleotide dissociation stimulator
External IDsMGI: 107485 HomoloGene: 4562 GeneCards: RALGDS
Gene location (Human)
Chr.Chromosome 9 (human)[1]
BandNo data availableStart133,097,720 bp[1]
End133,149,334 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5900

19730

Ensembl

ENSG00000160271

ENSMUSG00000026821

UniProt

Q12967

Q03385

RefSeq (mRNA)

NM_006266
NM_001042368
NM_001271774
NM_001271775
NM_001271776

NM_001145834
NM_001145835
NM_001145836
NM_009058

RefSeq (protein)

NP_001035827
NP_001258703
NP_001258704
NP_001258705
NP_006257

NP_001139306
NP_001139307
NP_001139308
NP_033084

Location (UCSC)Chr 9: 133.1 – 133.15 MbChr 9: 28.51 – 28.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ral guanine nucleotide dissociation stimulator is a protein that in humans is encoded by the RALGDS gene.[5][6]

Interactions

RALGDS has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160271 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026821 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Hofer F, Fields S, Schneider C, Martin GS (December 1994). "Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator". Proc Natl Acad Sci U S A. 91 (23): 11089–93. PMC 45172 Freely accessible. PMID 7972015. doi:10.1073/pnas.91.23.11089.
  6. ↑ "Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator".
  7. 1 2 Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS (August 2002). "Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization". Nat. Cell Biol. 4 (8): 547–55. PMID 12105416. doi:10.1038/ncb821.
  8. 1 2 3 4 Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. PMC 45488 Freely accessible. PMID 7809086. doi:10.1073/pnas.91.26.12609.
  9. 1 2 Boettner B, Govek EE, Cross J, Van Aelst L (August 2000). "The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9064–9. PMC 16822 Freely accessible. PMID 10922060. doi:10.1073/pnas.97.16.9064.
  10. 1 2 Li W, Han M, Guan KL (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8): 895–900. PMC 316541 Freely accessible. PMID 10783161.
  11. ↑ Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. PMID 15031288. doi:10.1074/jbc.M312867200.
  12. ↑ Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL (February 1997). "RalGDS functions in Ras- and cAMP-mediated growth stimulation". J. Biol. Chem. 272 (9): 5600–5. PMID 9038168. doi:10.1074/jbc.272.9.5600.
  13. ↑ Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J (May 1997). "Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras". Cell. 89 (3): 457–67. PMID 9150145. doi:10.1016/s0092-8674(00)80226-3.
  14. ↑ Stang S, Bottorff D, Stone JC (June 1997). "Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells". Mol. Cell. Biol. 17 (6): 3047–55. PMC 232157 Freely accessible. PMID 9154803.
  15. ↑ Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (November 1997). "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution". Oncogene. 15 (22): 2675–85. PMID 9400994. doi:10.1038/sj.onc.1201674.
  16. ↑ Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (October 1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood. 94 (7): 2433–44. PMID 10498616.
  17. 1 2 Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (March 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. PMID 10085114. doi:10.1074/jbc.274.13.8737.

Further reading

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