RAB5C

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4KYI

Identifiers

Aliases

RAB5C, L1880, RAB5CL, RAB5L, RABL, member RAS oncogene family

External IDs

MGI: 105306 HomoloGene: 55533 GeneCards: RAB5C

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	No data available	Start	42,124,976 bp^[1]
Band	No data available	End	42,155,044 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	No data available	Start	100,715,009 bp^[2]
Band	No data available	End	100,738,215 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• nucleotide binding • GTP binding • protein binding • GDP binding • GTPase activity
Cellular component	• melanosome • lysosomal membrane • endosome • lipid droplet • endocytic vesicle • early endosome • extracellular exosome • membrane • plasma membrane • early endosome membrane • azurophil granule membrane • intracellular
Biological process	• protein transport • regulation of endocytosis • plasma membrane to endosome transport • neutrophil degranulation • membrane organization • transport • small GTPase mediated signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5878


19345

Ensembl


ENSG00000108774


ENSMUSG00000019173

UniProt


P51148


P35278

RefSeq (mRNA)


NM_001252039 NM_004583 NM_201434


NM_024456 NM_001305003

RefSeq (protein)


NP_001238968 NP_004574 NP_958842


NP_001291932 NP_077776

Location (UCSC)

Chr 17: 42.12 – 42.16 Mb

Chr 17: 100.72 – 100.74 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-5C is a protein that in humans is encoded by the RAB5C gene.^[5]^[6] RAB5C belongs to the Ras-related protein family.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000108774 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019173 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Han HJ, Sudo K, Inazawa J, Nakamura Y (Jul 1996). "Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene". Cytogenet Cell Genet. 73 (1-2): 137–9. PMID 8646882. doi:10.1159/000134325.
↑ "Entrez Gene: RAB5C RAB5C, member RAS oncogene family".

Albertsen HM, Smith SA, Mazoyer S, et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21.". Nat. Genet. 7 (4): 472–9. PMID 7951316. doi:10.1038/ng0894-472.
Alvarez-Dominguez C, Stahl PD (1999). "Interferon-gamma selectively induces Rab5a synthesis and processing in mononuclear cells.". J. Biol. Chem. 273 (51): 33901–4. PMID 9852039. doi:10.1074/jbc.273.51.33901.
Bucci C, Chiariello M, Lattero D, et al. (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1).". Biochem. Biophys. Res. Commun. 258 (3): 657–62. PMID 10329441. doi:10.1006/bbrc.1999.0651.
Clemens DL, Lee BY, Horwitz MA (2000). "Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate.". Infect. Immun. 68 (5): 2671–84. PMC 97474 . PMID 10768959. doi:10.1128/IAI.68.5.2671-2684.2000.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Merithew E, Stone C, Eathiraj S, Lambright DG (2003). "Determinants of Rab5 interaction with the N terminus of early endosome antigen 1.". J. Biol. Chem. 278 (10): 8494–500. PMID 12493736. doi:10.1074/jbc.M211514200.
Kajiho H, Saito K, Tsujita K, et al. (2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.". J. Cell. Sci. 116 (Pt 20): 4159–68. PMID 12972505. doi:10.1242/jcs.00718.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135–44. PMID 17081065. doi:10.1021/pr060363j.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

PDB gallery

1huq: 1.8A CRYSTAL STRUCTURE OF THE MONOMERIC GTPASE RAB5C (MOUSE)

1n6h: Crystal Structure of Human Rab5a

1n6i: Crystal Structure of Human Rab5a A30P mutant Complex with GDP

1n6k: Crystal Structure of Human Rab5a A30P mutant complex with GDP and aluminum fluoride

1n6l: Crystal Structure of Human Rab5a A30P mutant complex with GTP

1n6n: Crystal Structure of Human Rab5a A30R mutant complex with GppNHp

1n6o: Crystal Structure of Human Rab5a A30K mutant complex with GppNHp

1n6p: Crystal Structure of Human Rab5a A30E mutant complex with GppNHp

1n6r: Crystal Structure of Human Rab5a A30L mutant complex with GppNHp

1r2q: Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution

1tu3: Crystal Structure of Rab5 complex with Rabaptin5 C-terminal Domain

1tu4: Crystal Structure of Rab5-GDP Complex

1z07: GppNHp-Bound Rab5c G55Q mutant GTPase

1z0d: GDP-Bound Rab5c GTPase

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RAB5C

References

Further reading