RAB1B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3JZA, 3NKV, 4HLQ, 4I1O

Identifiers

Aliases

RAB1B, member RAS oncogene family

External IDs

MGI: 1923558 HomoloGene: 128838 GeneCards: RAB1B

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	No data available	Start	66,268,533 bp^[1]
Band	No data available	End	66,277,492 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	No data available	Start	5,099,207 bp^[2]
Band	No data available	End	5,106,996 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• nucleotide binding • GTP binding • protein binding • GTPase activity
Cellular component	• cytoplasm • pre-autophagosomal structure membrane • Golgi apparatus • membrane • Golgi membrane • transport vesicle • mitochondrion • extracellular exosome • endoplasmic reticulum-Golgi intermediate compartment membrane • endoplasmic reticulum-Golgi intermediate compartment • endoplasmic reticulum membrane • cytosol
Biological process	• establishment of endothelial intestinal barrier • virion assembly • positive regulation of glycoprotein metabolic process • autophagy • regulation of autophagosome assembly • ER to Golgi vesicle-mediated transport • COPII vesicle coating • protein transport • retrograde vesicle-mediated transport, Golgi to ER • post-translational protein modification • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


81876


76308

Ensembl


ENSG00000174903


ENSMUSG00000024870

UniProt


Q9H0U4


Q9D1G1

RefSeq (mRNA)


NM_030981


NM_029576

RefSeq (protein)


NP_112243


NP_083852

Location (UCSC)

Chr 11: 66.27 – 66.28 Mb

Chr 11: 5.1 – 5.11 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-1B is a protein that in humans is encoded by the RAB1B gene.^[5]^[6]

Interactions

RAB1B has been shown to interact with GOLGA2.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174903 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024870 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Chen D, Guo J, Gahl WA (March 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6. PMID 9030196. doi:10.1016/S0167-4889(96)00169-3.
↑ "Entrez Gene: RAB1B RAB1B, member RAS oncogene family".
↑ Weide, T; Bayer M; Köster M; Siebrasse J P; Peters R; Barnekow A (April 2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. England. 2 (4): 336–41. ISSN 1469-221X. PMC 1083862 . PMID 11306556. doi:10.1093/embo-reports/kve065.

Plutner H, Cox AD, Pind S, et al. (1991). "Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments". J. Cell Biol. 115 (1): 31–43. PMC 2289927 . PMID 1918138. doi:10.1083/jcb.115.1.31.
Soldati T, Rancaño C, Geissler H, Pfeffer SR (1995). "Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes". J. Biol. Chem. 270 (43): 25541–8. PMID 7592724. doi:10.1074/jbc.270.43.25541.
Wilson AL, Sheridan KM, Erdman RA, Maltese WA (1996). "Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells". Biochem. J. 318 (Pt 3): 1007–14. PMC 1217717 . PMID 8836150. doi:10.1042/bj3181007.
Overmeyer JH, Wilson AL, Erdman RA, Maltese WA (1998). "The Putative "Switch 2" Domain of the Ras-related GTPase, Rab1B, Plays an Essential Role in the Interaction with Rab Escort Protein". Mol. Biol. Cell. 9 (1): 223–35. PMC 25245 . PMID 9437002. doi:10.1091/mbc.9.1.223.
Weide T, Koster M, Barnekow A (1999). "Inactive and active mutants of rab1b are not tightly integrated into target membranes". Int. J. Oncol. 15 (4): 727–36. PMID 10493955. doi:10.3892/ijo.15.4.727.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
Weide T, Bayer M, Köster M, et al. (2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. 2 (4): 336–41. PMC 1083862 . PMID 11306556. doi:10.1093/embo-reports/kve065.
Zhao H, Ettala O, Väänänen HK (2002). "Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins". Biochem. Biophys. Res. Commun. 293 (3): 1060–5. PMID 12051767. doi:10.1016/S0006-291X(02)00326-1.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. PMID 15694364. doi:10.1016/j.bbrc.2004.12.182.
Bayer M, Fischer J, Kremerskothen J, et al. (2006). "Identification and characterization of Iporin as a novel interaction partner for rab1". BMC Cell Biol. 6: 15. PMC 1079803 . PMID 15796781. doi:10.1186/1471-2121-6-15.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.
Monetta P, Slavin I, Romero N, Alvarez C (2007). "Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association". Mol. Biol. Cell. 18 (7): 2400–10. PMC 1924811 . PMID 17429068. doi:10.1091/mbc.E06-11-1005.
Machner MP, Isberg RR (2007). "A bifunctional bacterial protein links GDI displacement to Rab1 activation". Science. 318 (5852): 974–7. PMID 17947549. doi:10.1126/science.1149121.

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RAB1B

Interactions

References

Further reading