QKI

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4JVH

Identifiers

Aliases

QKI, Hqk, QK, QK1, QK3, hqkI, KH domain containing, RNA binding, KH domain containing RNA binding

External IDs

MGI: 97837 HomoloGene: 11059 GeneCards: QKI

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	No data available	Start	163,414,000 bp^[1]
Band	No data available	End	163,578,596 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 17 (mouse)^[2]

Band	No data available	Start	10,206,471 bp^[2]
Band	No data available	End	10,319,361 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• SH3 domain binding • protein binding • nucleic acid binding • mRNA binding • RNA binding
Cellular component	• cytoplasm • nucleus
Biological process	• cell differentiation • mRNA transport • mRNA processing • vasculogenesis • multicellular organism development • axon ensheathment • muscle cell differentiation • positive regulation of gene expression • long-chain fatty acid biosynthetic process • RNA splicing • spermatid development • myelination • 3'-UTR-mediated mRNA destabilization • regulation of translation • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9444


19317

Ensembl


ENSG00000112531


ENSMUSG00000062078

UniProt


Q96PU8


Q9QYS9

RefSeq (mRNA)


NM_001301085 NM_006775 NM_206853 NM_206854 NM_206855


NM_001159516 NM_001159517 NM_021881

RefSeq (protein)


NP_001288014 NP_006766 NP_996735 NP_996736 NP_996737


NP_001152988 NP_001152989 NP_068681

Location (UCSC)

Chr 6: 163.41 – 163.58 Mb

Chr 6: 10.21 – 10.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.^[5]^[6]

QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA.^[7] They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1 .^[8] Two more new members are KHDRBS3^[9] and KHDRBS2.^[10]

The QKI gene is implicated as being important in schizophrenia,^[11]^[12] and QKI controls translation of many oligodendrocyte-related genes.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112531 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062078 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: QKI quaking homolog, KH domain RNA binding (mouse)".
↑ Saccomanno L, Loushin C, Jan E, Punkay E, Artzt K, Goodwin EB (October 1999). "The STAR protein QKI-6 is a translational repressor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12605–10. Bibcode:1999PNAS...9612605S. PMC 23011 . PMID 10535969. doi:10.1073/pnas.96.22.12605.
↑ Vernet C, Artzt K (December 1997). "STAR, a gene family involved in signal transduction and activation of RNA". Trends Genet. 13 (12): 479–84. PMID 9433137. doi:10.1016/S0168-9525(97)01269-9.
↑ Chen T, Richard S (August 1998). "Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization". Mol. Cell. Biol. 18 (8): 4863–71. PMC 109071 . PMID 9671495.
↑ Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC (June 1999). "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis". Hum. Mol. Genet. 8 (6): 959–69. PMID 10332027. doi:10.1093/hmg/8.6.959.
↑ Wang L, Xu J, Zeng L, Ye X, Wu Q, Dai J, Ji C, Gu S, Zhao C, Xie Y, Mao Y (December 2002). "Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2". Mol. Biol. Rep. 29 (4): 369–75. PMID 12549823. doi:10.1023/A:1021246109101.
↑ Aberg K, Saetre P, Jareborg N, Jazin E (May 2006). "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7482–7. Bibcode:2006PNAS..103.7482A. PMC 1464365 . PMID 16641098. doi:10.1073/pnas.0601213103.
↑ Haroutunian V, Katsel P, Dracheva S, Davis KL (October 2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". Am J Psychiatry. 163 (10): 1834–7. PMID 17012699. doi:10.1176/ajp.2006.163.10.1834.

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics. 23 (1): 42–50. PMID 7829101. doi:10.1006/geno.1994.1457.
Saccomanno L, Loushin C, Jan E, et al. (1999). "The STAR protein QKI-6 is a translational repressor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12605–10. Bibcode:1999PNAS...9612605S. PMC 23011 . PMID 10535969. doi:10.1073/pnas.96.22.12605.
Li ZZ, Kondo T, Murata T, et al. (2002). "Expression of Hqk encoding a KH RNA binding protein is altered in human glioma.". Jpn. J. Cancer Res. 93 (2): 167–77. PMID 11856480. doi:10.1111/j.1349-7006.2002.tb01255.x.
Wu JI, Reed RB, Grabowski PJ, Artzt K (2002). "Function of quaking in myelination: regulation of alternative splicing". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4233–8. Bibcode:2002PNAS...99.4233W. PMC 123631 . PMID 11917126. doi:10.1073/pnas.072090399.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Moore FL, Jaruzelska J, Fox MS, et al. (2003). "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 538–43. Bibcode:2003PNAS..100..538M. PMC 141031 . PMID 12511597. doi:10.1073/pnas.0234478100.
Côté J, Boisvert FM, Boulanger MC, et al. (2003). "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1.". Mol. Biol. Cell. 14 (1): 274–87. PMC 140244 . PMID 12529443. doi:10.1091/mbc.E02-08-0484.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. PMID 16189514. doi:10.1038/nature04209.
Ichimura K, Mungall AJ, Fiegler H, et al. (2006). "Small regions of overlapping deletions on 6q26 in human astrocytic tumours identified using chromosome 6 tile path array-CGH.". Oncogene. 25 (8): 1261–71. PMC 2760128 . PMID 16205629. doi:10.1038/sj.onc.1209156.
Aberg K, Saetre P, Lindholm E, et al. (2006). "Human QKI, a new candidate gene for schizophrenia involved in myelination.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (1): 84–90. PMID 16342280. doi:10.1002/ajmg.b.30243.
Aberg K, Saetre P, Jareborg N, Jazin E (2006). "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7482–7. Bibcode:2006PNAS..103.7482A. PMC 1464365 . PMID 16641098. doi:10.1073/pnas.0601213103.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell. 125 (4): 801–14. PMID 16713569. doi:10.1016/j.cell.2006.03.032.
Haroutunian V, Katsel P, Dracheva S, Davis KL (2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia.". The American Journal of Psychiatry. 163 (10): 1834–7. PMID 17012699. doi:10.1176/ajp.2006.163.10.1834.
Zhao L, Tian D, Xia M, et al. (2006). "Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI.". J. Neurosci. 26 (44): 11278–86. PMID 17079655. doi:10.1523/JNEUROSCI.2677-06.2006.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

QKI

References

Further reading