Pyroglutamyl-peptidase II

Pyroglutamyl-peptidase II
Identifiers
EC number 3.4.19.6
CAS number 60063-88-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Pyroglutamyl-peptidase II (EC 3.4.19.6, thyroliberinase, pyroglutamyl aminopeptidase II, thyrotropin-releasing factor pyroglutamate aminopeptidase, pyroglutamate aminopeptidase II, pyroglutamyl peptidase II, thyroliberin-hydrolyzing pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase, thyrotropin-releasing hormone-degrading peptidase, TRH aminopeptidase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Release of the N-terminal pyroglutamyl group from pGlu--His-Xaa tripeptides and pGlu--His-Xaa-Gly tetrapeptides

This enzyme is highly specific for thyrotropin releasing hormone.

References

  1. ↑ Bauer, K.; Nowak, P. (1979). "Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond". Eur. J. Biochem. 99: 239–246. PMID 115687. doi:10.1111/j.1432-1033.1979.tb13250.x.
  2. ↑ O'Connor, B.; O'Cuinn, G. (1985). "Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain". Eur. J. Biochem. 150: 47–52. PMID 2862039. doi:10.1111/j.1432-1033.1985.tb08986.x.
  3. ↑ Wilk, S.; Wilk, E.K. (1989). "Pyroglutamyl peptidase II, a thyrotropin releasing hormone degrading enzyme: purification and specificity studies of the rabbit brain enzyme". Neurochem. Int. 15: 81–89. doi:10.1016/0197-0186(89)90079-x.
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