Protopine
Names | |
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IUPAC name
7-Methyl-6,8,9,16-tetrahydrobis[1,3]benzodioxolo[4,5-c:5′,6′-g]azecin-15(7H)-one | |
Identifiers | |
3D model (JSmol) |
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ChEBI | |
ChemSpider | |
ECHA InfoCard | 100.004.546 |
EC Number | 204-999-6 |
KEGG | |
PubChem CID |
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Properties | |
C20H19NO5 | |
Molar mass | 353.369 g/mol |
Appearance | white crystals |
Density | 1.399 g/cm3 |
Melting point | 208 °C (406 °F; 481 K) |
practically insoluble | |
Solubility in chloroform | 1:15 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
Protopine is a benzylisoquinoline alkaloid occurring in opium poppy,[2] Corydalis tubers[3] and other plants of the family papaveraceae, like Fumaria officinalis.[4] It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.[5][6]
See also
References
- ↑ The Merck Index (9 ed.). New Jersey: Merck & Co. 1976. p. 1023.
- ↑ The Free Dictionary: Protopine
- ↑ Jiang, B; Cao, K; Wang, R (2004). "Inhibitory effect of protopine on K(ATP) channel subunits expressed in HEK-293 cells.". European Journal of Pharmacology. 506 (2): 93–100. PMID 15588728. doi:10.1016/j.ejphar.2004.11.004.
- ↑ Vrba, J.; Vrublova, E.; Modriansky, M.; Ulrichova, J. (2011). "Protopine and allocryptopine increase mRNA levels of cytochromes P450 1A in human hepatocytes and HepG2 cells independently of AhR". Toxicology Letters. 203 (2): 135–141. PMID 21419197. doi:10.1016/j.toxlet.2011.03.015.
- ↑ Saeed, SA; Gilani, AH; Majoo, RU; Shah, BH (1997). "Anti-thrombotic and anti-inflammatory activities of protopine.". Pharmacological research : the official journal of the Italian Pharmacological Society. 36 (1): 1–7. PMID 9368908. doi:10.1006/phrs.1997.0195.
- ↑ Protopine at the US National Library of Medicine Medical Subject Headings (MeSH)
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