REL
The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene.[5] The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.[6]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000162924 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020275 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Ruben SM, Klement JF, Coleman TA, Maher M, Chen CH, Rosen CA (Jun 1992). "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev. 6 (5): 745–60. PMID 1577270. doi:10.1101/gad.6.5.745.
- ↑ Gilmore TD, Kalaitzidis D, Liang MC, Starczynowski DT (March 2004). "The c-Rel transcription factor and B-cell proliferation: a deal with the devil". Oncogene. 23 (13): 2275–86. PMID 14755244. doi:10.1038/sj.onc.1207410.
Further reading
- Rayet B, Gélinas C (2000). "Aberrant rel/nfkb genes and activity in human cancer.". Oncogene. 18 (49): 6938–47. PMID 10602468. doi:10.1038/sj.onc.1203221.
- Kunsch C, Ruben SM, Rosen CA (1992). "Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.". Mol. Cell. Biol. 12 (10): 4412–21. PMC 360365
. PMID 1406630. - Neumann M, Tsapos K, Scheppler JA, et al. (1992). "Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B.". Oncogene. 7 (11): 2095–104. PMID 1437141.
- Kochel T, Rice NR (1992). "v-rel- and c-rel-protein complexes bind to the NF-kappa B site in vitro.". Oncogene. 7 (3): 567–72. PMID 1549370.
- Kumar S, Rabson AB, Gélinas C (1992). "The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.". Mol. Cell. Biol. 12 (7): 3094–106. PMC 364524 . PMID 1620118.
- Lu D, Thompson JD, Gorski GK, et al. (1991). "Alterations at the rel locus in human lymphoma.". Oncogene. 6 (7): 1235–41. PMID 1650444.
- Muchardt C, Seeler JS, Nirula A, et al. (1992). "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products.". J. Virol. 66 (1): 244–50. PMC 238281 . PMID 1727488.
- Hansen SK, Nerlov C, Zabel U, et al. (1992). "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.". EMBO J. 11 (1): 205–13. PMC 556441 . PMID 1740106.
- Davis N, Ghosh S, Simmons DL, et al. (1991). "Rel-associated pp40: an inhibitor of the rel family of transcription factors.". Science. 253 (5025): 1268–71. PMID 1891714. doi:10.1126/science.1891714.
- Lim MY, Davis N, Zhang JY, Bose HR (1990). "The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70.". Virology. 175 (1): 149–60. PMID 2155506. doi:10.1016/0042-6822(90)90195-W.
- Brownell E, Mittereder N, Rice NR (1989). "A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon.". Oncogene. 4 (7): 935–42. PMID 2666912.
- Brownell E, O'Brien SJ, Nash WG, Rice N (1986). "Genetic characterization of human c-rel sequences.". Mol. Cell. Biol. 5 (10): 2826–31. PMC 367021 . PMID 3016517.
- Brownell E, Kozak CA, Fowle JR, et al. (1986). "Comparative genetic mapping of cellular rel sequences in man, mouse, and the domestic cat.". Am. J. Hum. Genet. 39 (2): 194–202. PMC 1683919 . PMID 3529946.
- John S, Reeves RB, Lin JX, et al. (1995). "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.". Mol. Cell. Biol. 15 (3): 1786–96. PMC 230403 . PMID 7862168. doi:10.1128/mcb.15.3.1786.
- Xu X, Gélinas C (1995). "The v-Rel oncoprotein complexes with new Rel- and RelA-related proteins in transformed cells.". Virology. 207 (2): 362–8. PMID 7886940. doi:10.1006/viro.1995.1095.
- Mackman N (1994). "Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers.". J. Biol. Chem. 269 (42): 26363–7. PMID 7929355.
- Sif S, Gilmore TD (1994). "Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1.". J. Virol. 68 (11): 7131–8. PMC 237152 . PMID 7933095.
- Hansen SK, Baeuerle PA, Blasi F (1994). "Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription.". Mol. Cell. Biol. 14 (4): 2593–603. PMC 358627 . PMID 8139561. doi:10.1128/mcb.14.4.2593.
- Beg AA, Baldwin AS (1994). "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.". Oncogene. 9 (5): 1487–92. PMID 8152812.
External links
- Genes, rel at the US National Library of Medicine Medical Subject Headings (MeSH)
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