Proteasome endopeptidase complex
| Proteasome endopeptidase complex | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
Proteasome core particle, di-heptamer, Archaea | |||||||||
| Identifiers | |||||||||
| EC number | 3.4.25.1 | ||||||||
| CAS number | 140879-24-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Proteasome endopeptidase complex (EC 3.4.25.1, ingensin, macropain, multicatalytic endopeptidase complex, prosome, multicatalytic proteinase (complex), MCP, proteasome, large multicatalytic protease, proteasome organelle, alkaline protease, 26S protease, tricorn proteinase, tricorn protease) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Cleavage of peptide bonds with very broad specificity
This 20-S protein is composed of 28 subunits arranged in four rings of seven.
References
- ↑ Seemüller, E.; Lupas, A.; Stock, D.; Löwe, J.; Huber, R.; Baumeister, W. (1995). "Proteasome from Thermoplasma acidophilum: a threonine protease". Science. 268 (5210): 579–582. PMID 7725107. doi:10.1126/science.7725107.
- ↑ Coux, O.; Tanaka, K.; Goldberg, A.L. (1996). "Structure and functions of the 20S and 26S proteasomes". Annu. Rev. Biochem. 65: 801–847. PMID 8811196. doi:10.1146/annurev.bi.65.070196.004101.
- ↑ Groll, M.; Ditzel, L.; Löwe, J.; Stock, D.; Bochtler, M.; Bartunik, H.D.; Huber, R. (1997). "Structure of 20S proteasome from yeast at 2.4Å resolution". Nature. 386 (6624): 463–471. PMID 9087403. doi:10.1038/386463a0.
- ↑ Dick, T.P.; Nussbaum, A.K.; Deeg, M.; Heinemeyer, W.; Groll, M.; Schirle, M.; Keilholz, W.; Stevanovic, S.; Wolf, D.H.; Huber, R.; Rammensee, H.G.; Schild, H. (1998). "Contribution of proteasomal β-subunits to the cleavage of peptide substrates analyzed with yeast mutants". J. Biol. Chem. 273 (40): 25637–25646. PMID 9748229. doi:10.1074/jbc.273.40.25637.
External links
- Proteasome endopeptidase complex at the US National Library of Medicine Medical Subject Headings (MeSH)
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