Pitrazepin

Pitrazepin
Clinical data
Pregnancy
category
  • ?
Routes of
administration		 ?
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
Formula C19H19N5
Molar mass 317.39 g/mol
3D model (JSmol)

Pitrazepin is a competitive GABAA and glycine receptor antagonist.[1][2][3] It has been used to study insect and snail nervous systems in scientific research.[4][5][6][7][8][9]

See also

References

  1. ↑ Gähwiler BH, Maurer R, Wüthrich HJ (April 1984). "Pitrazepin, a novel GABAA antagonist". Neuroscience Letters. 45 (3): 311–6. PMID 6328380. doi:10.1016/0304-3940(84)90244-1.
  2. ↑ Braestrup C, Nielsen M (November 1985). "Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors". European Journal of Pharmacology. 118 (1-2): 115–21. PMID 3002806. doi:10.1016/0014-2999(85)90669-7.
  3. ↑ Curtis DR, Gynther BD (November 1986). "Pitrazepin: a central glycine and GABA antagonist". European Journal of Pharmacology. 131 (2-3): 311–3. PMID 3816960. doi:10.1016/0014-2999(86)90590-X.
  4. ↑ Anthony NM, Harrison JB, Sattelle DB (1993). "GABA receptor molecules of insects". Exs. 63: 172–209. PMID 7678525. doi:10.1007/978-3-0348-7265-2_8.
  5. ↑ Sattelle DB, Pinnock RD, Wafford KA, David JA (January 1988). "GABA receptors on the cell-body membrane of an identified insect motor neuron". Proceedings of the Royal Society B. 232 (1269): 443–56. PMID 2451252. doi:10.1098/rspb.1988.0006.
  6. ↑ Murphy VF, Wann KT (November 1988). "The action of GABA receptor agonists and antagonists on muscle membrane conductance in Schistocerca gregaria". British Journal of Pharmacology. 95 (3): 713–22. PMC 1854212 Freely accessible. PMID 2850061. doi:10.1111/j.1476-5381.1988.tb11697.x.
  7. ↑ Zhang W, Han XY, Wong SM, Takeuchi H (January 1997). "Pharmacologic characteristics of excitatory gamma-amino-butyric acid (GABA) receptors in a snail neuron". General Pharmacology. 28 (1): 45–53. PMID 9112076. doi:10.1016/S0306-3623(96)00152-8.
  8. ↑ Kim KH, Takeuchi H (June 1990). "Pharmacological characteristics of two different types of inhibitory GABA receptors on Achatina fulica neurones". European Journal of Pharmacology. 182 (1): 49–62. PMID 2169426. doi:10.1016/0014-2999(90)90492-O.
  9. ↑ Takeuchi H (September 1992). "Sensitivities of Achatina giant neurones to putative amino acid neurotransmitters". Comparative Biochemistry and Physiology C. 103 (1): 1–12. PMID 1360362. doi:10.1016/0742-8413(92)90219-w.


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