Pirbuterol
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| Clinical data | |
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| Trade names | Maxair |
| AHFS/Drugs.com | Consumer Drug Information |
| MedlinePlus | a601096 |
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| Routes of administration | Inhalational (MDI) |
| ATC code | |
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| Identifiers | |
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| DrugBank | |
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| Chemical and physical data | |
| Formula | C12H20N2O3 |
| Molar mass |
240.30 g/mol 300.3 g/mol (acetate) |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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Pirbuterol (trade name Maxair) is a short-acting β2 adrenoreceptor agonist with bronchodilating action used in the treatment of asthma, available (as pirbuterol acetate) as a breath-activated metered-dose inhaler (Maxair Autohaler).
Clinical use
Pirbuterol is used in asthma for reversal of acute bronchospasm, and also as a maintenance medication to prevent future attacks. It should be used in patients 12 years of age and older with or without concurrent theophylline and/or inhaled corticosteroid.[1][2]
Mode of action
Pharmacokinetics
After inhalation of doses up to 800 μg (twice the maximum recommended dose) systemic blood levels of pirbuterol are below the limit of assay sensitivity (2–5 ng/ml). A mean of 51% of the dose is recovered in urine as pirbuterol plus its sulfate conjugate following administration by aerosol. Pirbuterol is not metabolized by catechol-O-methyltransferase. The plasma half-life measured after oral administration is about two hours.[1]
Adverse effects
References
- 1 2 "Maxair Autohaler (pirbuterol acetate inhalation aerosol) For Oral Inhalation Only. U.S. Full Prescribing Information". 3M Pharmaceuticals. Northridge, CA 91324. Retrieved 7 March 2016.
- ↑ Bianchi, Marina; Clavenna, Antonio; Bonati, Maurizio (2010). "Inter-country variations in anti-asthmatic drug prescriptions for children. Systematic review of studies published during the 2000–2009 period". European Journal of Clinical Pharmacology. 66 (9): 929–936. ISSN 0031-6970. doi:10.1007/s00228-010-0845-y.