Peter C. Gøtzsche

Peter C. Gøtzsche (born 26 November 1949) is a Danish physician, medical researcher, and leader of the Nordic Cochrane Center at Rigshospitalet in Copenhagen, Denmark. He co-founded, and has written numerous reviews within the Cochrane collaboration.

Among his research findings are that placebo has surprisingly little effect[1][2][3] and that many meta-analyses may have data extraction errors.[4] Gøtzsche and his coauthors have been keen to criticize the research methods and interpretations of other scientists, e.g. in meta-analysis of placebo.[5][6]

Gøtzsche has commented on meta-analysis,[7] and the editorial independence of medical journals.[8] He has written about issues surrounding medical ghostwriting with the position that it is scientific misconduct.[9] He has also criticized the widespread use of SSRI antidepressants.[10]

Critique of mammography screening

Gøtzsche has been critical of screening for breast cancer using mammography, arguing that it cannot be justified; his critique has caused controversy.[11] His critique stems from a meta-analysis he did on mammography screening studies and published as Is screening for breast cancer with mammography justifiable? in The Lancet in 2000.[12] In it he discarded 6 out of 8 studies arguing their randomization was inadequate.

In 2006 a paper by Gøtzsche on mammography screening was electronically published in the European Journal of Cancer ahead of print.[13] The journal later removed the paper completely from the journal website without any formal retraction.[14] The paper was later published in Danish Medical Bulletin with a short note from the editor,[15] and Gøtzsche and his coauthors commented on the unilateral retraction that the authors were not involved in.[16]

In 2012 his book Mammography Screening: Truth, Lies and Controversy was published.[17] In 2013 his book Deadly Medicines and Organised Crime: How Big Pharma has Corrupted Healthcare was published.[18]

Books

Reports

References

  1. ↑ Asbjørn Hrobjartsson & Peter C. Gøtzsche (January 2002). "Hvad er effekten af placebobehandling? En systematisk oversigt over randomiserede kliniske forsøg med placebobehandlede og ubehandlede patienter [What is the effect of placebo interventions? A systematic review of randomised trials with placebo treated and untreated patients]". Ugeskrift for Læger. 164 (3): 329–333. PMID 11816328.
  2. ↑ Hróbjartsson, Asbjørn; Gøtzsche, Peter C. (2010-01-20). "Placebo interventions for all clinical conditions". The Cochrane Database of Systematic Reviews (1): CD003974. ISSN 1469-493X. PMID 20091554. doi:10.1002/14651858.CD003974.pub3.
  3. ↑ A. Hrobjartsson & P. C. Gotzsche (August 2004). "Is the placebo powerless? Update of a systematic review with 52 new randomized trials comparing placebo with no treatment". Journal of Internal Medicine. 256 (2): 91–100. PMID 15257721. doi:10.1111/j.1365-2796.2004.01355.x.
  4. ↑ Peter C. Gøtzsche; Asbjørn Hróbjartsson; Katja Maric; Britta Tendal (July 2007). "Data Extraction Errors in Meta-analyses That Use Standardized Mean Differences". JAMA. 298 (4): 430–437. PMID 17652297. doi:10.1001/jama.298.4.430. There is a error in the article. Comments:
  5. ↑ Asbjørn Hróbjartssona & Peter C. Gøtzsche (April 2006). "Unsubstantiated claims of large effects of placebo on pain: serious errors in meta-analysis of placebo analgesia mechanism studies". Journal of Clinical Epidemiology. 59 (4): 336–338. PMID 16549252. doi:10.1016/j.jclinepi.2005.05.011.
  6. ↑ Asbjørn Hróbjartsson, Peter C. Gøtzsche (2007). "Powerful spin in the conclusion of wampold et al.'s re-analysis of placebo versus no-treatment trials despite similar results as in original review". Journal of Clinical Psychology. 63 (4): 373–377. PMID 17279532. doi:10.1002/jclp.20357.
  7. ↑ Peter C. Gøtzsche (September 2000). "Why we need a broad perspective on meta-analysis". BMJ. 321 (7261): 585–586. doi:10.1136/bmj.321.7261.585.
  8. ↑ Peter C. Gøtzsche (2008). "Ytringsfrihed og redaktionel uafhængighed: Fire fyringer og en kafkask proces" (PDF). Ugeskrift for Læger. 170 (18): 1537.
  9. ↑ Peter C. Gøtzsche; Jerome P. Kassirer; Karen L. Woolley; Elizabeth Wager; Adam Jacobs; Art Gertel; Cindy Hamilton (2009). "What Should Be Done To Tackle Ghostwriting in the Medical Literature?". PLoS Medicine. 6 (2): e1000023. PMC 2634793 Freely accessible. PMID 19192943. doi:10.1371/journal.pmed.1000023.
  10. ↑ Gotzsche, Peter (30 April 2014). "Psychiatric drugs are doing us more harm than good". The Guardian. Retrieved 25 November 2014.
  11. ↑ Donald G. McNeil, Jr. (2002-04-09). "CONFRONTING CANCER: SCIENTIST AT WORK -- PETER GOTZSCHE; A Career That Bristles With Against-the-Grain Conclusions". New York Times.
  12. ↑ Peter C. Gøtzsche; Ole Olsen (January 2000). "Is screening for breast cancer with mammography justifiable?". The Lancet. 355: 129+. doi:10.1016/S0140-6736(99)06065-1.
  13. ↑ Zahl, PH; Gøtzsche, PC; Andersen, JM; Mæhlen, J (March 2006). "WITHDRAWN: Results of the Two-County trial of mammography screening are not compatible with contemporaneous official Swedish breast cancer statistics". European Journal of Cancer. PMID 16530407. doi:10.1016/j.ejca.2005.12.016.
  14. ↑ Kerry Grens (December 2006). "Mammography article withdrawal sparks dispute". The Scientist.
  15. ↑ Per-Henrik Zahl; Peter C. Gøtzsche; Jannike Mørch Andersen; Jan Mæhlen (November 2006). "Results of the Two-County trial of mammography screening are not compatible with contemporaneous official Swedish breast cancer statistics". Danish Medical Bulletin. 53: 438–440. PMID 16530407. doi:10.1016/j.ejca.2005.12.016. Archived from the original on June 21, 2007.
  16. ↑ Peter C Gøtzsche; Jan Mæhlen; Per-Henrik Zahl (November–December 2006). "What is a publication?". The Lancet. 368 (9550): 1854–1856. doi:10.1016/S0140-6736(06)69756-0.
  17. ↑ Gøtzsche, Peter C (2012). Mammography Screening: Truth, Lies and Controversy. Milton Keynes: Radcliffe Publishing Ltd. p. 400. ISBN 978-1-84619-585-3.
  18. ↑ Gotzsche, Peter (2013). Deadly Medicines and Organised Crime: How Big Pharma has Corrupted Healthcare. Radcliffe. ISBN 9781846198847.
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