Perivascular administration

Perivascular systems, also referred to as periadventitial (Greek περί; perí, “around” the vessel or the adventitia) systems, are intended for the local treatment of focal vascular pathologies. Perivascular medical devices [1] [2]and perivascular drug delivery systems [3] [4] are conceived for local application around a blood vessel during open vascular surgery. These systems provide mechanical support and/or pharmacological activity for the prevention of intimal hyperplasia following vessel injury.In contrast to stents placed endovasculary when minimally invasive percutaneous interventions are performed, perivascular systems are conceived to improve the outcome of coronary or peripheral bypass interventions, arteriovenous fistulas placements and carotid surgery .

  1. ↑ V. Vijayan, F.C.T. Smith, G.D. Angelini, R.A. Bulbulia, J.Y. Jeremy, External Supports and the Prevention of Neointima Formation in Vein Grafts, Eur. J. Vasc. Endovasc. Surg. 24(1) (2002) 13-22.
  2. ↑ M. Desai, J. Mirzay-Razzaz, D.D. von, S. Sarkar, G. Hamilton, A.M. Seifalian, Inhibition of neointimal formation and hyperplasia in vein grafts by external stent/sheath, Vasc. Med. 15(4) (2010) 287-97.
  3. ↑ M.A. Chaudhary, L.-W. Guo, X. Shi, G. Chen, S. Gong, B. Liu, K.C. Kent, Periadventitial drug delivery for the prevention of intimal hyperplasia following open surgery, J. Control. Release 233 (2016) 174-180.
  4. ↑ Mylonaki, I., Allémann, É., Saucy, F., Haefliger, J.-A., Delie, F., Jordan, O., 2017. Perivascular medical devices and drug delivery systems: Making the right choices. Biomaterials 128, 56-68
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