PTPN3

PTPN3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPTPN3, PTP-H1, PTPH1, protein tyrosine phosphatase, non-receptor type 3
External IDsMGI: 105307 HomoloGene: 74451 GeneCards: PTPN3
Gene location (Human)
Chr.Chromosome 9 (human)[1]
BandNo data availableStart109,375,466 bp[1]
End109,498,313 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5774

545622

Ensembl

ENSG00000070159

ENSMUSG00000038764

UniProt

P26045

A2ALK8

RefSeq (mRNA)

NM_011207

RefSeq (protein)

NP_035337

Location (UCSC)Chr 9: 109.38 – 109.5 MbChr 9: 57.19 – 57.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 3 is an enzyme that in humans is encoded by the PTPN3 gene.[5][6]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta.[6]

Interactions

PTPN3 has been shown to interact with YWHAB.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000070159 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038764 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Yang Q, Tonks NK (August 1991). "Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin". Proc Natl Acad Sci USA. 88 (14): 5949–53. PMC 51999 Freely accessible. PMID 1648725. doi:10.1073/pnas.88.14.5949.
  6. 1 2 "Entrez Gene: PTPN3 protein tyrosine phosphatase, non-receptor type 3".
  7. ↑ Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK (October 1997). "Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein". J. Biol. Chem. 272 (43): 27281–7. PMID 9341175. doi:10.1074/jbc.272.43.27281.

Further reading

  • Arimura Y, Hinoda Y, Itoh F, Takekawa M, Tsujisaki M, Adachi M, Imai K, Yachi A (1992). "cDNA cloning of new protein tyrosine phosphatases in the human colon.". Tumour Biol. 13 (3): 180–6. PMID 1626183. doi:10.1159/000217763. 
  • Ikuta S, Itoh F, Hinoda Y, Toyota M, Makiguchi Y, Imai K, Yachi A (1995). "Expression of cytoskeletal-associated protein tyrosine phosphatase PTPH1 mRNA in human hepatocellular carcinoma.". J. Gastroenterol. 29 (6): 727–32. PMID 7874267. doi:10.1007/BF02349278. 
  • Itoh F, Ikuta S, Hinoda Y, Arimura Y, Ohe M, Adachi M, Ariyama T, Inazawa J, Imai K, Yachi A (1994). "Expression and chromosomal assignment of PTPH1 gene encoding a cytosolic protein tyrosine phosphatase homologous to cytoskeletal-associated proteins.". Int. J. Cancer. 55 (6): 947–51. PMID 8253532. doi:10.1002/ijc.2910550612. 
  • Zhang SH, Kobayashi R, Graves PR, Piwnica-Worms H, Tonks NK (1997). "Serine phosphorylation-dependent association of the band 4.1-related protein-tyrosine phosphatase PTPH1 with 14-3-3beta protein.". J. Biol. Chem. 272 (43): 27281–7. PMID 9341175. doi:10.1074/jbc.272.43.27281. 
  • Zhang SH, Liu J, Kobayashi R, Tonks NK (1999). "Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1.". J. Biol. Chem. 274 (25): 17806–12. PMID 10364224. doi:10.1074/jbc.274.25.17806. 
  • Gjörloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T (2000). "Subcellular localization of intracellular protein tyrosine phosphatases in T cells.". Eur. J. Immunol. 30 (8): 2412–21. PMID 10940933. doi:10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J. 
  • Zheng Y, Schlondorff J, Blobel CP (2003). "Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1.". J. Biol. Chem. 277 (45): 42463–70. PMID 12207026. doi:10.1074/jbc.M207459200. 
  • Sozio MS, Mathis MA, Young JA, Wälchli S, Pitcher LA, Wrage PC, Bartók B, Campbell A, Watts JD, Aebersold R, Hooft van Huijsduijnen R, van Oers NS (2004). "PTPH1 is a predominant protein-tyrosine phosphatase capable of interacting with and dephosphorylating the T cell receptor zeta subunit.". J. Biol. Chem. 279 (9): 7760–9. PMID 14672952. doi:10.1074/jbc.M309994200. 
  • Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML (2005). "Substrate-trapping techniques in the identification of cellular PTP targets.". Methods. 35 (1): 44–53. PMID 15588985. doi:10.1016/j.ymeth.2004.07.007. 
  • Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics. 4 (6): 785–95. PMID 15778465. doi:10.1074/mcp.M500021-MCP200. 
  • Jespersen T, Gavillet B, van Bemmelen MX, Cordonier S, Thomas MA, Staub O, Abriel H (2006). "Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1.". Biochem. Biophys. Res. Commun. 348 (4): 1455–62. PMID 16930557. doi:10.1016/j.bbrc.2006.08.014. 
  • Jing M, Bohl J, Brimer N, Kinter M, Vande Pol SB (2007). "Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins.". J. Virol. 81 (5): 2231–9. PMC 1865939 Freely accessible. PMID 17166906. doi:10.1128/JVI.01979-06. 
  • Töpffer S, Müller-Schiffmann A, Matentzoglu K, Scheffner M, Steger G (2007). "Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses.". J. Gen. Virol. 88 (Pt 11): 2956–65. PMID 17947517. doi:10.1099/vir.0.83123-0. 


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