PSME4

Identifiers

PSME4, PA200, proteasome activator subunit 4

External IDs

MGI: 2143994 HomoloGene: 113742 GeneCards: PSME4

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	No data available	Start	53,864,067 bp^[1]
Band	No data available	End	53,970,840 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	No data available	Start	30,771,726 bp^[2]
Band	No data available	End	30,880,361 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding • peptidase activator activity • lysine-acetylated histone binding • proteasome binding
Cellular component	• cytoplasm • nuclear speck • proteasome complex • nucleus • nucleoplasm • cytosol • proteasome core complex • spermatoproteasome complex
Biological process	• cell differentiation • regulation of cellular amino acid metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • regulation of mRNA stability • positive regulation of canonical Wnt signaling pathway • protein polyubiquitination • stimulatory C-type lectin receptor signaling pathway • tumor necrosis factor-mediated signaling pathway • MAPK cascade • cellular response to DNA damage stimulus • positive regulation of peptidase activity • multicellular organism development • Fc-epsilon receptor signaling pathway • NIK/NF-kappaB signaling • spermatogenesis • anaphase-promoting complex-dependent catabolic process • T cell receptor signaling pathway • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • negative regulation of canonical Wnt signaling pathway • DNA repair • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway, planar cell polarity pathway • proteasomal ubiquitin-independent protein catabolic process • negative regulation of G2/M transition of mitotic cell cycle • protein deubiquitination • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process • spermatogenesis, exchange of chromosomal proteins • transmembrane transport • regulation of transcription from RNA polymerase II promoter in response to hypoxia • post-translational protein modification • regulation of hematopoietic stem cell differentiation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23198


103554

Ensembl


ENSG00000068878


ENSMUSG00000040850

UniProt


Q14997


Q5SSW2

RefSeq (mRNA)


NM_014614


NM_134013

RefSeq (protein)


NP_055429


NP_598774

Location (UCSC)

Chr 2: 53.86 – 53.97 Mb

Chr 2: 30.77 – 30.88 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Proteasome activator complex subunit 4 is a protein that in humans is encoded by the PSME4 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000068878 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040850 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. PMID 7584044. doi:10.1093/dnares/1.5.223.
↑ Ustrell V, Hoffman L, Pratt G, Rechsteiner M (Jul 2002). "PA200, a nuclear proteasome activator involved in DNA repair". The EMBO Journal. 21 (13): 3516–25. PMC 126083 . PMID 12093752. doi:10.1093/emboj/cdf333.
↑ "Entrez Gene: PSME4 proteasome (prosome, macropain) activator subunit 4".

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Proteasome endopeptidase complex subunits (EC 3.4.25.1)
A (alpha subunits)	PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8
B (beta subunits)	PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMB10
C (ATPases)	PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6
D (non-ATPases)	PSMD1 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14
E (activator subunits)	PSME1 PSME2 PSME3 PSME4
F (inhibitor subunit)	PSMF1

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PSME4

References

Further reading