PRMT2

PRMT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRMT2, HRMT1L1, protein arginine methyltransferase 2
External IDsMGI: 1316652 HomoloGene: 55587 GeneCards: PRMT2
EC number2.1.1.125
Gene location (Human)
Chr.Chromosome 21 (human)[1]
BandNo data availableStart46,635,167 bp[1]
End46,665,124 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

3275

15468

Ensembl

ENSG00000160310

ENSMUSG00000020230

UniProt

P55345

Q9R144

RefSeq (mRNA)

NM_001077638
NM_133182
NM_001302965

RefSeq (protein)

n/a

Location (UCSC)Chr 21: 46.64 – 46.67 MbChr 21: 76.21 – 76.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein arginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene.[5][6]

Interactions

PRMT2 has been shown to interact with Estrogen receptor alpha[7] and HNRPUL1.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000160310 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020230 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF (Jun 1998). "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)". Genomics. 48 (3): 330–40. PMID 9545638. doi:10.1006/geno.1997.5190.
  6. "Entrez Gene: PRMT2 protein arginine methyltransferase 2".
  7. Qi, Chao; Chang Jeffrey; Zhu Yiwei; Yeldandi Anjana V; Rao Sambasiva M; Zhu Yi-Jun (Aug 2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. United States. 277 (32): 28624–30. ISSN 0021-9258. PMID 12039952. doi:10.1074/jbc.M201053200.
  8. Kzhyshkowska, J; Schütt H; Liss M; Kremmer E; Stauber R; Wolf H; Dobner T (Sep 2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. England. 358 (Pt 2): 305–14. ISSN 0264-6021. PMC 1222062Freely accessible. PMID 11513728. doi:10.1042/0264-6021:3580305.

Further reading


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