PPP2R1A

PPP2R1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPP2R1A, PP2A-Aalpha, PP2AAALPHA, PR65A, MRD36, protein phosphatase 2 scaffold subunit Aalpha, PP2AA
External IDsMGI: 1926334 HomoloGene: 68559 GeneCards: PPP2R1A
Gene location (Human)
Chr.Chromosome 19 (human)[1]
BandNo data availableStart52,190,039 bp[1]
End52,229,533 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5518

51792

Ensembl

ENSG00000105568

ENSMUSG00000007564

UniProt

P30153

Q76MZ3

RefSeq (mRNA)

NM_014225

NM_016891

RefSeq (protein)

NP_055040
NP_055040.2

NP_058587

Location (UCSC)Chr 19: 52.19 – 52.23 MbChr 19: 20.95 – 20.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene.[5] In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).[6]

Function

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.[7]

Interactions

PPP2R1A has been shown to interact with:

Arabidopsis RCN1

RCN1 At1g25490 is one of three genes in Arabidopsis encoding Phosphoprotein Phosphatase 2A Regulatory Subunit A (PP2Aa). The association of different b subunits with a PP2Aa-PP2ac dimer is believed to determine substrate specificity.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105568 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000007564 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Everett AD, Xue C, Stoops T (August 1999). "Developmental expression of protein phosphatase 2A in the kidney". J. Am. Soc. Nephrol. 10 (8): 1737–45. PMID 10446941.
  6. ↑ Haynes JG, Hartung AJ, Hendershot JD, Passingham RS, Rundle SJ (February 1999). "Molecular characterization of the B' regulatory subunit gene family of Arabidopsis protein phosphatase 2A". Eur. J. Biochem. 260 (1): 127–136. PMID 10091592. doi:10.1046/j.1432-1327.1999.00154.x.
  7. ↑ "Entrez Gene: PPP2R1A protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform".
  8. 1 2 3 4 5 6 7 8 9 10 Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (January 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell Proteomics. 8 (1): 157–171. PMC 2621004 Freely accessible. PMID 18782753. doi:10.1074/mcp.M800266-MCP200.
  9. 1 2 3 4 5 Zhou J, Pham HT, Ruediger R, Walter G (January 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". Biochem. J. 369 (Pt 2): 387–98. PMC 1223084 Freely accessible. PMID 12370081. doi:10.1042/BJ20021244.
  10. ↑ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (October 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". J. Biol. Chem. 283 (43): 29273–29284. PMC 2662017 Freely accessible. PMID 18715871. doi:10.1074/jbc.M803443200.
  11. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 Freely accessible. PMID 17353931. doi:10.1038/msb4100134.

Further reading

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