PPP2CB

Identifiers

PPP2CB, PP2Abeta, PP2CB, protein phosphatase 2 catalytic subunit beta

External IDs

MGI: 1321161 HomoloGene: 37889 GeneCards: PPP2CB

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	No data available	Start	30,774,457 bp^[1]
Band	No data available	End	30,814,314 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	No data available	Start	33,599,625 bp^[2]
Band	No data available	End	33,619,441 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• phosphoprotein phosphatase activity • metal ion binding • protein binding • hydrolase activity • protein serine/threonine phosphatase activity • protein C-terminus binding
Cellular component	• cytoplasm • cytosol • spindle pole • protein phosphatase type 2A complex • chromosome • chromosome, centromeric region • extracellular exosome • cytoskeleton • nucleus
Biological process	• response to antibiotic • response to endoplasmic reticulum stress • apoptotic mitochondrial changes • regulation of gene expression • response to hydrogen peroxide • proteasome-mediated ubiquitin-dependent protein catabolic process • protein dephosphorylation • negative regulation of Ras protein signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5516


19053

Ensembl


ENSG00000104695


ENSMUSG00000009630

UniProt


P62714


P62715

RefSeq (mRNA)


NM_004156 NM_001009552


NM_017374

RefSeq (protein)


NP_001009552


NP_059070

Location (UCSC)

Chr 8: 30.77 – 30.81 Mb

Chr 8: 33.6 – 33.62 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP2CB gene.^[5]

Function

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. Two transcript variants encoding the same protein have been identified for this gene.^[6]

Interactions

PPP2CB has been shown to interact with TLX1,^[7] PPP2R1B^[8] and PPP2R1A.^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104695 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000009630 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Jones TA, Barker HM, da Cruz e Silva EF, Mayer-Jaekel RE, Hemmings BA, Spurr NK, Sheer D, Cohen PT (April 1993). "Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively". Cytogenetics and Cell Genetics. 63 (1): 35–41. PMID 8383590. doi:10.1159/000133497.
↑ "Entrez Gene: PPP2CB protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform".
↑ Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. PMID 9009195. doi:10.1038/385454a0.
1 2 Zhou J, Pham HT, Ruediger R, Walter G (Jan 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". The Biochemical Journal. 369 (Pt 2): 387–98. PMC 1223084 . PMID 12370081. doi:10.1042/BJ20021244.
↑ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. PMC 2621004 . PMID 18782753. doi:10.1074/mcp.M800266-MCP200.

Zolnierowicz S (Oct 2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochemical Pharmacology. 60 (8): 1225–35. PMID 11007961. doi:10.1016/S0006-2952(00)00424-X.
Goedert M, Cohen ES, Jakes R, Cohen P (Nov 1992). "p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]". FEBS Letters. 312 (1): 95–9. PMID 1330687. doi:10.1016/0014-5793(92)81418-L.
Khew-Goodall Y, Mayer RE, Maurer F, Stone SR, Hemmings BA (Jan 1991). "Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes". Biochemistry. 30 (1): 89–97. PMID 1846293. doi:10.1021/bi00215a014.
Pallas DC, Shahrik LK, Martin BL, Jaspers S, Miller TB, Brautigan DL, Roberts TM (Jan 1990). "Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A". Cell. 60 (1): 167–76. PMID 2153055. doi:10.1016/0092-8674(90)90726-U.
Virshup DM, Kauffman MG, Kelly TJ (Dec 1989). "Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A". The EMBO Journal. 8 (12): 3891–8. PMC 402079 . PMID 2555176.
Arino J, Woon CW, Brautigan DL, Miller TB, Johnson GL (Jun 1988). "Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes". Proceedings of the National Academy of Sciences of the United States of America. 85 (12): 4252–6. PMC 280405 . PMID 2837763. doi:10.1073/pnas.85.12.4252.
Hemmings BA, Wernet W, Mayer R, Maurer F, Hofsteenge J, Stone SR (Dec 1988). "The nucleotide sequence of the cDNA encoding the human lung protein phosphatase 2A beta catalytic subunit". Nucleic Acids Research. 16 (23): 11366. PMC 339017 . PMID 2849765. doi:10.1093/nar/16.23.11366.
Favre B, Zolnierowicz S, Turowski P, Hemmings BA (Jun 1994). "The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo". The Journal of Biological Chemistry. 269 (23): 16311–7. PMID 8206937.
Keranen LM, Dutil EM, Newton AC (Dec 1995). "Protein kinase C is regulated in vivo by three functionally distinct phosphorylations". Current Biology. 5 (12): 1394–1403. PMID 8749392. doi:10.1016/S0960-9822(95)00277-6.
Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2-3): 197–201. PMID 9013886. doi:10.1016/S0014-5793(96)01470-6.
Nagase T, Murakami T, Nozaki H, Inoue R, Nishito Y, Tanabe O, Usui H, Takeda M (Jul 1997). "Tissue and subcellular distributions, and characterization of rat brain protein phosphatase 2A containing a 72-kDa delta/B" subunit". Journal of Biochemistry. 122 (1): 178–87. PMID 9276686. doi:10.1093/oxfordjournals.jbchem.a021726.
Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology. 238 (2): 432–43. PMID 9400615. doi:10.1006/viro.1997.8873.
Hsu W, Zeng L, Costantini F (Feb 1999). "Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain". The Journal of Biological Chemistry. 274 (6): 3439–45. PMID 9920888. doi:10.1074/jbc.274.6.3439.
Ogris E, Du X, Nelson KC, Mak EK, Yu XX, Lane WS, Pallas DC (May 1999). "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A". The Journal of Biological Chemistry. 274 (20): 14382–91. PMC 3503312 . PMID 10318862. doi:10.1074/jbc.274.20.14382.
De Baere I, Derua R, Janssens V, Van Hoof C, Waelkens E, Merlevede W, Goris J (Dec 1999). "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue". Biochemistry. 38 (50): 16539–47. PMID 10600115. doi:10.1021/bi991646a.
Götz J, Probst A, Mistl C, Nitsch RM, Ehler E (May 2000). "Distinct role of protein phosphatase 2A subunit Calpha in the regulation of E-cadherin and beta-catenin during development". Mechanisms of Development. 93 (1-2): 83–93. PMID 10781942. doi:10.1016/S0925-4773(00)00267-7.
Lüss H, Klein-Wiele O, Bokník P, Herzig S, Knapp J, Linck B, Müller FU, Scheld HH, Schmid C, Schmitz W, Neumann J (Dec 2000). "Regional expression of protein phosphatase type 1 and 2A catalytic subunit isoforms in the human heart". Journal of Molecular and Cellular Cardiology. 32 (12): 2349–59. PMID 11113010. doi:10.1006/jmcc.2000.1265.

PDB gallery

2iae: Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.

2ie3: Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins

2ie4: Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid

2npp: Structure of the Protein Phosphatase 2A Holoenzyme

2nyl: Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated

2nym: Crystal Structure of Protein Phosphatase 2A (PP2A) with C-terminus truncated catalytic subunit

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PPP2CB

Function

Interactions

See also

References

Further reading