PPARGC1B
Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.[5][6][7]
See also
- PPARGC1A
- Peroxisome proliferator-activated receptor
- Peroxisome proliferator-activated receptor alpha
- Peroxisome proliferator-activated receptor delta
- Peroxisome proliferator-activated receptor gamma
- Transcription coregulator
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000155846 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033871 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O (Jan 2002). "Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus". Diabetologia. 44 (12): 2220–6. PMID 11793024. doi:10.1007/s001250100032.
- ↑ Kressler D, Schreiber SN, Knutti D, Kralli A (Apr 2002). "The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha". J Biol Chem. 277 (16): 13918–25. PMID 11854298. doi:10.1074/jbc.M201134200.
- ↑ "Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta".
External links
- PPARGC1B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C21
Further reading
- Handschin C, Spiegelman BM (2007). "Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.". Endocr. Rev. 27 (7): 728–35. PMID 17018837. doi:10.1210/er.2006-0037.
- Esterbauer H, Oberkofler H, Krempler F, Patsch W (2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression.". Genomics. 62 (1): 98–102. PMID 10585775. doi:10.1006/geno.1999.5977.
- Knutti D, Kaul A, Kralli A (2000). "A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen.". Mol. Cell. Biol. 20 (7): 2411–22. PMC 85422
. PMID 10713165. doi:10.1128/MCB.20.7.2411-2422.2000. - Lin J, Puigserver P, Donovan J, et al. (2002). "Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.". J. Biol. Chem. 277 (3): 1645–8. PMID 11733490. doi:10.1074/jbc.C100631200.
- Lacquemant C, Chikri M, Boutin P, et al. (2002). "No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians.". Diabetologia. 45 (4): 602–3; author reply 604. PMID 12032643. doi:10.1007/s00125-002-0783-z.
- Hara K, Tobe K, Okada T, et al. (2003). "A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.". Diabetologia. 45 (5): 740–3. PMID 12107756. doi:10.1007/s00125-002-0803-z.
- Huss JM, Kopp RP, Kelly DP (2002). "Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha.". J. Biol. Chem. 277 (43): 40265–74. PMID 12181319. doi:10.1074/jbc.M206324200.
- Hentschke M, Süsens U, Borgmeyer U (2003). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma.". Biochem. Biophys. Res. Commun. 299 (5): 872–9. PMID 12470660. doi:10.1016/S0006-291X(02)02753-5.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Shiraki T, Sakai N, Kanaya E, Jingami H (2003). "Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state.". J. Biol. Chem. 278 (13): 11344–50. PMID 12551939. doi:10.1074/jbc.M212859200.
- Hammarstedt A, Jansson PA, Wesslau C, et al. (2003). "Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance.". Biochem. Biophys. Res. Commun. 301 (2): 578–82. PMID 12565902. doi:10.1016/S0006-291X(03)00014-7.
- Meirhaeghe A, Crowley V, Lenaghan C, et al. (2003). "Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo.". Biochem. J. 373 (Pt 1): 155–65. PMC 1223480 . PMID 12678921. doi:10.1042/BJ20030200.
- Patti ME, Butte AJ, Crunkhorn S, et al. (2003). "Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8466–71. PMC 166252 . PMID 12832613. doi:10.1073/pnas.1032913100.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Ling C, Poulsen P, Carlsson E, et al. (2004). "Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.". J. Clin. Invest. 114 (10): 1518–26. PMC 525741 . PMID 15546003. doi:10.1172/JCI21889.
- Andersen G, Wegner L, Yanagisawa K, et al. (2006). "Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.". J. Med. Genet. 42 (5): 402–7. PMC 1736055 . PMID 15863669. doi:10.1136/jmg.2004.026278.
- Staiger H, Staiger K, Haas C, et al. (2005). "Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro.". Diabetologia. 48 (10): 2115–8. PMID 16132959. doi:10.1007/s00125-005-1895-z.
- Wirtenberger M, Tchatchou S, Hemminki K, et al. (2006). "Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer.". Carcinogenesis. 27 (11): 2201–8. PMID 16704985. doi:10.1093/carcin/bgl067.
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