POLR2J

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
5FLM, 5IY9, 5IYA, 5IYC, 5IYB, 5IY7, 5IY8, 5IYD, 5IY6

Identifiers

Aliases

POLR2J, POLR2J1, RPB11, RPB11A, RPB11m, hRPB14, polymerase (RNA) II subunit J, RNA polymerase II subunit J

External IDs

MGI: 109582 HomoloGene: 4542 GeneCards: POLR2J

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	No data available	Start	102,473,118 bp^[1]
Band	No data available	End	102,478,907 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	No data available	Start	136,116,631 bp^[2]
Band	No data available	End	136,122,947 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• DNA binding • LRR domain binding • protein dimerization activity • RNA polymerase II activity • DNA-directed 5'-3' RNA polymerase activity • protein binding
Cellular component	• nucleoplasm • DNA-directed RNA polymerase II, core complex • nucleus
Biological process	• mRNA splicing, via spliceosome • somatic stem cell population maintenance • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • transcription from RNA polymerase II promoter • positive regulation of viral transcription • transcription-coupled nucleotide-excision repair • transcription initiation from RNA polymerase II promoter • snRNA transcription from RNA polymerase II promoter • fibroblast growth factor receptor signaling pathway • transcription, DNA-templated • RNA metabolic process • regulation of gene silencing by miRNA
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5439


20022

Ensembl


ENSG00000005075


ENSMUSG00000039771

UniProt


P52435


O08740

RefSeq (mRNA)


NM_006234


NM_011293

RefSeq (protein)


NP_006225


n/a

Location (UCSC)

Chr 7: 102.47 – 102.48 Mb

Chr 7: 136.12 – 136.12 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB11-a is an enzyme that in humans is encoded by the POLR2J gene.

Function

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13.^[5]

Interactions

POLR2J has been shown to interact with:

Apoptosis antagonizing transcription factor,^[6]
POLR2C,^[7]^[8] and
SATB1.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000005075 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039771 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa".
↑ Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (May 2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB J. 14 (7): 904–12. PMID 10783144.
↑ Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27): 16815–21. PMID 9201987. doi:10.1074/jbc.272.27.16815.
↑ Corbi N, Di Padova M, De Angelis R, Bruno T, Libri V, Iezzi S, Floridi A, Fanciulli M, Passananti C (October 2002). "The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin". FASEB J. 16 (12): 1639–41. PMID 12207009. doi:10.1096/fj.02-0123fje.
↑ Durrin LK, Krontiris TG (June 2002). "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics. 79 (6): 809–17. PMID 12036295. doi:10.1006/geno.2002.6772.

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POLR2J

Function

Interactions

References

Further reading