POLR1B

POLR1B

Identifiers

POLR1B, RPA135, RPA2, Rpo1-2, polymerase (RNA) I subunit B, RNA polymerase I subunit B

External IDs

MGI: 108014 HomoloGene: 7133 GeneCards: POLR1B

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	No data available	Start	112,541,915 bp^[1]
Band	No data available	End	112,577,150 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	No data available	Start	129,100,995 bp^[2]
Band	No data available	End	129,126,594 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity • DNA binding • nucleotidyltransferase activity • ribonucleoside binding • metal ion binding • DNA-directed 5'-3' RNA polymerase activity • protein binding • RNA polymerase I activity
Cellular component	• nucleoplasm • nucleolus • DNA-directed RNA polymerase I complex • nucleus • cytosol
Biological process	• termination of RNA polymerase I transcription • positive regulation of gene expression, epigenetic • transcription initiation from RNA polymerase I promoter • rRNA transcription • transcription, DNA-templated • transcription elongation from RNA polymerase I promoter • embryo implantation • nucleologenesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


84172


20017


ENSG00000125630


ENSMUSG00000027395


Q9H9Y6


P70700

RefSeq (mRNA)

NM_019014 NM_001137604 NM_001282772 NM_001282774 NM_001282776
NM_001282777 NM_001282779


NM_009086

RefSeq (protein)

NP_001131076 NP_001269701 NP_001269703 NP_001269705 NP_001269706
NP_001269708 NP_061887


NP_033112

Location (UCSC)

Chr 2: 112.54 – 112.58 Mb

Chr 2: 129.1 – 129.13 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

DNA-directed RNA polymerase I subunit RPA2 is an enzyme that in humans is encoded by the POLR1B gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000125630 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027395 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: POLR1B polymerase (RNA) I polypeptide B, 128kDa".

Further reading

Seither P, Zatsepina O, Hoffmann M, Grummt I (1997). "Constitutive and strong association of PAF53 with RNA polymerase I.". Chromosoma. 106 (4): 216–25. PMID 9254723. doi:10.1007/s004120050242.
Miller G, Panov KI, Friedrich JK (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. PMC 145519 . PMID 11250903. doi:10.1093/emboj/20.6.1373.
Seither P, Iben S, Thiry M, Grummt I (2002). "PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I". Biol. Chem. 382 (8): 1163–70. PMID 11592397. doi:10.1515/BC.2001.146.
Shiau AK, Barstad D, Radek JT (2002). "Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism". Nat. Struct. Biol. 9 (5): 359–64. PMID 11953755. doi:10.1038/nsb787.
Egea PF, Mitschler A, Moras D (2002). "Molecular recognition of agonist ligands by RXRs". Mol. Endocrinol. 16 (5): 987–97. PMID 11981034. doi:10.1210/me.16.5.987.
Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Bouwmeester T, Bauch A, Ruffner H (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. PMID 14743216. doi:10.1038/ncb1086.
Yamamoto K, Yamamoto M, Hanada K (2004). "Multiple Protein-Protein Interactions by RNA Polymerase I-Associated Factor PAF49 and Role of PAF49 in rRNA Transcription". Mol. Cell. Biol. 24 (14): 6338–49. PMC 434256 . PMID 15226435. doi:10.1128/MCB.24.14.6338-6349.2004.
Philimonenko VV, Zhao J, Iben S (2005). "Nuclear actin and myosin I are required for RNA polymerase I transcription". Nat. Cell Biol. 6 (12): 1165–72. PMID 15558034. doi:10.1038/ncb1190.
Hillier LW, Graves TA, Fulton RS (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. PMID 15815621. doi:10.1038/nature03466.
Zhang C, Comai L, Johnson DL (2005). "PTEN Represses RNA Polymerase I Transcription by Disrupting the SL1 Complex". Mol. Cell. Biol. 25 (16): 6899–911. PMC 1190253 . PMID 16055704. doi:10.1128/MCB.25.16.6899-6911.2005.
Percipalle P, Fomproix N, Cavellán E (2006). "The chromatin remodelling complex WSTF–SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription". EMBO Rep. 7 (5): 525–30. PMC 1479564 . PMID 16514417. doi:10.1038/sj.embor.7400657.
Panova TB, Panov KI, Russell J, Zomerdijk JC (2006). "Casein Kinase 2 Associates with Initiation-Competent RNA Polymerase I and Has Multiple Roles in Ribosomal DNA Transcription". Mol. Cell. Biol. 26 (16): 5957–68. PMC 1592790 . PMID 16880508. doi:10.1128/MCB.00673-06.
Johnson SS, Zhang C, Fromm J (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases". Mol. Cell. 26 (3): 367–79. PMID 17499043. doi:10.1016/j.molcel.2007.03.021.

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