POLQ

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4X0P, 4X0Q, 5AGA, 5A9J, 5A9F

Identifiers

Aliases

POLQ, POLH, PRO0327, polymerase (DNA) theta, DNA polymerase theta

External IDs

MGI: 2155399 HomoloGene: 32727 GeneCards: POLQ

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	No data available	Start	121,431,427 bp^[1]
Band	No data available	End	121,546,641 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	No data available	Start	37,011,786 bp^[2]
Band	No data available	End	37,095,417 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity • nucleotide binding • DNA binding • nucleotidyltransferase activity • single-stranded DNA-dependent ATPase activity • 5'-deoxyribose-5-phosphate lyase activity • chromatin binding • damaged DNA binding • protein binding • nucleic acid binding • DNA-directed DNA polymerase activity • ATP binding • 5'-3' exonuclease activity
Cellular component	• nucleoplasm • chromosome • nucleus • cytoplasm
Biological process	• somatic hypermutation of immunoglobulin genes • negative regulation of double-strand break repair via homologous recombination • double-strand break repair via alternative nonhomologous end joining • cellular response to DNA damage stimulus • DNA replication • double-strand break repair via homologous recombination • protein homooligomerization • DNA repair • base-excision repair • DNA biosynthetic process • double-strand break repair • DNA-dependent DNA replication
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10721


77782

Ensembl


ENSG00000051341


ENSMUSG00000034206

UniProt


O75417


Q8CGS6

RefSeq (mRNA)


NM_199420


NM_001159369 NM_029977

RefSeq (protein)


NP_955452


NP_001152841 NP_084253

Location (UCSC)

Chr 3: 121.43 – 121.55 Mb

Chr 3: 37.01 – 37.1 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA polymerase theta is an enzyme that in humans is encoded by the POLQ gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000051341 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034206 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Sharief FS, Vojta PJ, Ropp PA, Copeland WC (Aug 1999). "Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase". Genomics. 59 (1): 90–6. PMID 10395804. doi:10.1006/geno.1999.5843.
↑ "Entrez Gene: POLQ polymerase (DNA directed), theta".

Hogg M, Sauer-Eriksson AE, Johansson E (2012). "Promiscuous DNA synthesis by human DNA polymerase θ.". Nucleic Acids Research. 40 (6): 2611–2622. PMC 3315306 . PMID 22135286. doi:10.1093/nar/gkr1102.
Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics. 23 (1): 42–50. PMID 7829101. doi:10.1006/geno.1994.1457.
Maga G, Shevelev I, Ramadan K, et al. (2002). "DNA polymerase theta purified from human cells is a high-fidelity enzyme.". J. Mol. Biol. 319 (2): 359–69. PMID 12051913. doi:10.1016/S0022-2836(02)00325-X.
Seki M, Marini F, Wood RD (2003). "POLQ (Pol θ), a DNA polymerase and DNA-dependent ATPase in human cells". Nucleic Acids Res. 31 (21): 6117–26. PMC 275456 . PMID 14576298. doi:10.1093/nar/gkg814.
Kawamura K, Bahar R, Seimiya M, et al. (2004). "DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers". Int. J. Cancer. 109 (1): 9–16. PMID 14735462. doi:10.1002/ijc.11666.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. PMC 515316 . PMID 15342556. doi:10.1101/gr.2435604.
Seki M, Masutani C, Yang LW, et al. (2005). "High-efficiency bypass of DNA damage by human DNA polymerase Q". EMBO J. 23 (22): 4484–94. PMC 526458 . PMID 15496986. doi:10.1038/sj.emboj.7600424.
Chiapperino D, Cai M, Sayer JM, et al. (2006). "Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene". J. Biol. Chem. 280 (48): 39684–92. PMID 16188888. doi:10.1074/jbc.M508008200.
Zan H, Shima N, Xu Z, et al. (2005). "The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation". EMBO J. 24 (21): 3757–69. PMC 1276717 . PMID 16222339. doi:10.1038/sj.emboj.7600833.
Cruet-Hennequart S, Coyne S, Glynn MT, et al. (2006). "UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK". DNA Repair (Amst.). 5 (4): 491–504. PMID 16520097. doi:10.1016/j.dnarep.2006.01.008.
Chen YW, Cleaver JE, Hanaoka F, et al. (2006). "A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents". Mol. Cancer Res. 4 (4): 257–65. PMID 16603639. doi:10.1158/1541-7786.MCR-05-0118.
Yuasa MS, Masutani C, Hirano A, et al. (2006). "A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest". Genes Cells. 11 (7): 731–44. PMID 16824193. doi:10.1111/j.1365-2443.2006.00974.x.
Choi JY, Stover JS, Angel KC, et al. (2006). "Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site". J. Biol. Chem. 281 (35): 25297–306. PMID 16835218. doi:10.1074/jbc.M605699200.
Kino K, Ito N, Sugasawa K, et al. (2007). "Translesion synthesis by human DNA polymerase eta across oxidative products of guanine". Nucleic Acids Symp Ser (Oxf). 48 (1): 171–2. PMID 17150533. doi:10.1093/nass/48.1.171.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

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POLQ

References

Further reading