PLSCR1

PLSCR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPLSCR1, MMTRA1B, phospholipid scramblase 1
External IDsMGI: 893575 HomoloGene: 41418 GeneCards: PLSCR1
Gene location (Human)
Chr.Chromosome 3 (human)[1]
BandNo data availableStart146,515,180 bp[1]
End146,544,864 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

5359

22038

Ensembl

ENSG00000188313

ENSMUSG00000032369

UniProt

O15162

Q9JJ00

RefSeq (mRNA)

NM_021105

NM_011636

RefSeq (protein)

NP_066928

NP_035766

Location (UCSC)Chr 3: 146.52 – 146.54 MbChr 3: 92.25 – 92.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phospholipid scramblase 1 is an enzyme that in humans is encoded by the PLSCR1 gene.[5][6]

Interactions

PLSCR1 has been shown to interact with:

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000188313 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032369 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ (August 1997). "Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids". J Biol Chem. 272 (29): 18240–4. PMID 9218461. doi:10.1074/jbc.272.29.18240.
  6. ↑ "Entrez Gene: PLSCR1 phospholipid scramblase 1".
  7. 1 2 3 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
  8. 1 2 Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ (May 2002). "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor". Biochemistry. 41 (20): 6338–45. PMID 12009895. doi:10.1021/bi025610l.
  9. ↑ Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T (September 2003). "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor". J. Biol. Chem. 278 (39): 37413–8. PMID 12871937. doi:10.1074/jbc.M306182200.
  10. ↑ Tseng CC, Tseng CP (June 2000). "Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement". FEBS Lett. 475 (3): 232–6. PMID 10869562. doi:10.1016/s0014-5793(00)01700-2.

Further reading

  • Bassé F, Stout JG, Sims PJ, Wiedmer T (1996). "Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid.". J. Biol. Chem. 271 (29): 17205–10. PMID 8663431. doi:10.1074/jbc.271.29.17205. 
  • Zhou Q, Sims PJ, Wiedmer T (1998). "Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids.". Biochemistry. 37 (8): 2356–60. PMID 9485382. doi:10.1021/bi972625o. 
  • Zhao J, Zhou Q, Wiedmer T, Sims PJ (1998). "Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids.". Biochemistry. 37 (18): 6361–6. PMID 9572851. doi:10.1021/bi980218m. 
  • Kasukabe T, Kobayashi H, Kaneko Y, Okabe-Kado J, Honma Y (1998). "Identity of human normal counterpart (MmTRA1b) of mouse leukemogenesis-associated gene (MmTRA1a) product as plasma membrane phospholipid scramblase and chromosome mapping of the human MmTRA1b/phospholipid scramblase gene". Biochem. Biophys. Res. Commun. 249 (2): 449–55. PMID 9712717. doi:10.1006/bbrc.1998.9190. 
  • Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman RH, Sims PJ (2000). "Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha". Blood. 95 (8): 2593–9. PMID 10753839. 
  • Frasch SC, Henson PM, Kailey JM, Richter DA, Janes MS, Fadok VA, Bratton DL (2000). "Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta". J. Biol. Chem. 275 (30): 23065–73. PMID 10770950. doi:10.1074/jbc.M003116200. 
  • Tseng CC, Tseng CP (2000). "Identification of a novel secretory leukocyte protease inhibitor-binding protein involved in membrane phospholipid movement". FEBS Lett. 475 (3): 232–6. PMID 10869562. doi:10.1016/S0014-5793(00)01700-2. 
  • Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (2000). "Identification of three new members of the phospholipid scramblase gene family". Biochim. Biophys. Acta. 1467 (1): 244–53. PMID 10930526. doi:10.1016/S0005-2736(00)00236-4. 
  • Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T, Sims PJ (2001). "c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1". J. Biol. Chem. 276 (31): 28984–90. PMID 11390389. doi:10.1074/jbc.M102505200. 
  • Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ (2002). "Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1". Cancer Res. 62 (2): 397–402. PMID 11809687. 
  • Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ (2002). "Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor". Biochemistry. 41 (20): 6338–45. PMID 12009895. doi:10.1021/bi025610l. 
  • Zhou Q, Zhao J, Wiedmer T, Sims PJ (2002). "Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1". Blood. 99 (11): 4030–8. PMID 12010804. doi:10.1182/blood-2001-12-0271. 
  • Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS (2002). "Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase". J. Biol. Chem. 277 (31): 28051–7. PMID 12023963. doi:10.1074/jbc.M202665200. 
  • Nakamaki T, Okabe-Kado J, Yamamoto-Yamaguchi Y, Hino Ki, Tomoyasu S, Honma Y, Kasukabe T (2002). "Role of MmTRA1b/phospholipid scramblase1 gene expression in the induction of differentiation of human myeloid leukemia cells into granulocytes". Exp. Hematol. 30 (5): 421–9. PMID 12031648. doi:10.1016/S0301-472X(02)00779-8. 
  • Wiedmer T, Zhao J, Nanjundan M, Sims PJ (2003). "Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane". Biochemistry. 42 (5): 1227–33. PMID 12564925. doi:10.1021/bi026679w. 
  • Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y (2003). "Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))". J. Biol. Chem. 278 (17): 15239–45. PMID 12586838. doi:10.1074/jbc.M208611200. 
  • Rami A, Sims J, Botez G, Winckler J (2003). "Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia". Neurochem. Int. 43 (1): 79–87. PMID 12605885. doi:10.1016/S0197-0186(02)00194-8. 
  • Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T (2003). "Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor". J. Biol. Chem. 278 (39): 37413–8. PMID 12871937. doi:10.1074/jbc.M306182200. 


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