PIR (gene)
Pirin is a protein that in humans is encoded by the PIR gene.[5][6]
This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.[6]
Interactions
PIR (gene) has been shown to interact with BCL3.[7]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000087842 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031379 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein". J Biol Chem. 272 (13): 8482–9. PMID 9079676. doi:10.1074/jbc.272.13.8482.
- 1 2 "Entrez Gene: PIR pirin (iron-binding nuclear protein)".
- ↑ Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. ENGLAND. 18 (22): 3316–23. ISSN 0950-9232. PMID 10362352. doi:10.1038/sj.onc.1202717.
Further reading
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
- Adams M, Jia Z (2005). "Structural and biochemical analysis reveal pirins to possess quercetinase activity.". J. Biol. Chem. 280 (31): 28675–82. PMID 15951572. doi:10.1074/jbc.M501034200.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504. - Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
- Pang H, Bartlam M, Zeng Q, et al. (2004). "Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor.". J. Biol. Chem. 279 (2): 1491–8. PMID 14573596. doi:10.1074/jbc.M310022200.
- Zeng Q, Li X, Bartlam M, et al. (2004). "Purification, crystallization and preliminary X-ray analysis of human pirin.". Acta Crystallogr. D. 59 (Pt 8): 1496–8. PMID 12876364. doi:10.1107/S0907444903012289.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Dechend R, Hirano F, Lehmann K, et al. (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.". Oncogene. 18 (22): 3316–23. PMID 10362352. doi:10.1038/sj.onc.1202717.
PDB gallery | ||||
|---|---|---|---|---|
| ||||
This article is issued from
Wikipedia.
The text is licensed under Creative Commons - Attribution - Sharealike.
Additional terms may apply for the media files.