PIN4

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1EQ3, 1FJD, 3UI4, 3UI5, 3UI6

Identifiers

Aliases

PIN4, EPVH, PAR14, PAR17, peptidylprolyl cis/trans isomerase, NIMA-interacting 4

External IDs

MGI: 1916963 HomoloGene: 121907 GeneCards: PIN4

Gene location (Human)

Chr.	X chromosome (human)^[1]

Band	No data available	Start	72,181,353 bp^[1]
Band	No data available	End	72,302,926 bp^[1]

Gene location (Mouse)

Chr.	X chromosome (mouse)^[2]

Band	No data available	Start	102,119,447 bp^[2]
Band	No data available	End	102,127,669 bp^[2]

Gene ontology
Molecular function	• DNA binding • double-stranded DNA binding • protein binding • bent DNA binding • isomerase activity • peptidyl-prolyl cis-trans isomerase activity • RNA binding
Cellular component	• cytoplasm • mitochondrial matrix • spindle • preribosome • nucleolus • extracellular exosome • cytoskeleton • mitochondrion • nucleus
Biological process	• rRNA processing • protein peptidyl-prolyl isomerization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5303


69713

Ensembl


ENSG00000102309


ENSMUSG00000079480

UniProt


Q9Y237


Q9CWW6

RefSeq (mRNA)


NM_001170747 NM_006223


NM_027181

RefSeq (protein)


NP_001164218 NP_006214


XP_011249230

Location (UCSC)

Chr X: 72.18 – 72.3 Mb

Chr X: 102.12 – 102.13 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 is an enzyme that in humans is encoded by the PIN4 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102309 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079480 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Mueller JW, Kessler D, Neumann D, Stratmann T, Papatheodorou P, Hartmann-Fatu C, Bayer P (Mar 2006). "Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation". BMC Mol Biol. 7: 9. PMC 1420321 . PMID 16522211. doi:10.1186/1471-2199-7-9.
↑ Kessler D, Papatheodorou P, Stratmann T, Dian EA, Hartmann-Fatu C, Rassow J, Bayer P, Mueller JW (Oct 2007). "The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae". BMC Biol. 5: 37. PMC 2031878 . PMID 17875217. doi:10.1186/1741-7007-5-37.
↑ "Entrez Gene: PIN4 protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)".

Uchida T, Fujimori F, Tradler T, et al. (1999). "Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase.". FEBS Lett. 446 (2–3): 278–82. PMID 10100858. doi:10.1016/S0014-5793(99)00239-2.
Rulten S, Thorpe J, Kay J (1999). "Identification of eukaryotic parvulin homologues: a new subfamily of peptidylprolyl cis-trans isomerases". Biochem. Biophys. Res. Commun. 259 (3): 557–62. PMID 10364457. doi:10.1006/bbrc.1999.0828.
Sekerina E, Rahfeld JU, Müller J, et al. (2000). "NMR solution structure of hPar14 reveals similarity to the peptidyl prolyl cis/trans isomerase domain of the mitotic regulator hPin1 but indicates a different functionality of the protein". J. Mol. Biol. 301 (4): 1003–17. PMID 10966801. doi:10.1006/jmbi.2000.4013.
Terada T, Shirouzu M, Fukumori Y, et al. (2001). "Solution structure of the human parvulin-like peptidyl prolyl cis/trans isomerase, hPar14". J. Mol. Biol. 305 (4): 917–26. PMID 11162102. doi:10.1006/jmbi.2000.4293.
Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. PMC 311086 . PMID 11337467. doi:10.1101/gr.164001.
Fujiyama S, Yanagida M, Hayano T, et al. (2002). "Isolation and proteomic characterization of human Parvulin-associating preribosomal ribonucleoprotein complexes". J. Biol. Chem. 277 (26): 23773–80. PMID 11960984. doi:10.1074/jbc.M201181200.
Surmacz TA, Bayer E, Rahfeld JU, et al. (2002). "The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding". J. Mol. Biol. 321 (2): 235–47. PMID 12144781. doi:10.1016/S0022-2836(02)00615-0.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Reimer T, Weiwad M, Schierhorn A, et al. (2003). "Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14". J. Mol. Biol. 330 (5): 955–66. PMID 12860119. doi:10.1016/S0022-2836(03)00713-7.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

PIN4

References

Further reading