PIK3C3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3IHY, 3LS8, 4OYS, 4PH4, 4UWF, 4UWG, 4UWH, 4UWL, 5ANL

Identifiers

Aliases

PIK3C3, VPS34, hVps34, phosphatidylinositol 3-kinase catalytic subunit type 3

External IDs

MGI: 2445019 HomoloGene: 1986 GeneCards: PIK3C3

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	No data available	Start	41,955,206 bp^[1]
Band	No data available	End	42,087,830 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 18 (mouse)^[2]

Band	No data available	Start	30,272,747 bp^[2]
Band	No data available	End	30,348,126 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity • protein kinase activity • nucleotide binding • 1-phosphatidylinositol-3-kinase activity • protein binding • phosphatidylinositol 3-kinase activity • ATP binding • kinase activity
Cellular component	• cytosol • endosome • late endosome • phagocytic vesicle membrane • membrane • phosphatidylinositol 3-kinase complex, class III • autophagosome • midbody • phagocytic vesicle • axoneme • cytoplasmic vesicle • autolysosome • pre-autophagosomal structure • peroxisome • phosphatidylinositol 3-kinase complex, class III, type I • phosphatidylinositol 3-kinase complex, class III, type II • intracellular
Biological process	• cellular response to glucose starvation • regulation of cytokinesis • phosphorylation • protein processing • response to leucine • cytokinesis • endosome organization • cell division • phosphatidylinositol-3-phosphate biosynthetic process • phosphatidylinositol phosphorylation • early endosome to late endosome transport • phosphatidylinositol biosynthetic process • cell cycle • toll-like receptor 9 signaling pathway • macroautophagy • regulation of protein secretion • protein localization to pre-autophagosomal structure • cellular response to starvation • protein lipidation • autophagy • autophagosome assembly • protein phosphorylation • endocytosis • autophagy of peroxisome • phosphatidylinositol-mediated signaling
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5289


225326

Ensembl


ENSG00000078142


ENSMUSG00000033628

UniProt


Q8NEB9


Q6PF93

RefSeq (mRNA)


NM_001308020 NM_002647


NM_181414

RefSeq (protein)


NP_001294949 NP_002638


NP_852079

Location (UCSC)

Chr 18: 41.96 – 42.09 Mb

Chr 18: 30.27 – 30.35 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme that in humans is encoded by the PIK3C3 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000078142 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033628 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD (Sep 1995). "A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system". EMBO J. 14 (14): 3339–48. PMC 394401 . PMID 7628435.
↑ "Entrez Gene: PIK3C3 phosphoinositide-3-kinase, class 3".

Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.". J. Leukoc. Biol. 74 (5): 676–82. PMID 12960231. doi:10.1189/jlb.0503206.
Vogel LB, Fujita DJ (1994). "The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes.". Mol. Cell. Biol. 13 (12): 7408–17. PMC 364812 . PMID 7504174.
Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.". J. Biol. Chem. 271 (38): 22961–4. PMID 8798481. doi:10.1074/jbc.271.38.22961.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
Panaretou C, Domin J, Cockcroft S, Waterfield MD (1997). "Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex.". J. Biol. Chem. 272 (4): 2477–85. PMID 8999962. doi:10.1074/jbc.272.4.2477.
Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.". Eur. J. Immunol. 27 (9): 2457–65. PMID 9341793. doi:10.1002/eji.1830270946.
Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.". Eur. J. Immunol. 27 (11): 2805–11. PMID 9394803. doi:10.1002/eji.1830271110.
Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.". Biochem. Biophys. Res. Commun. 242 (2): 332–7. PMID 9446795. doi:10.1006/bbrc.1997.7877.
Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.". AIDS. 12 (11): 1275–84. PMID 9708406. doi:10.1097/00002030-199811000-00008.
Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.". Eur. J. Immunol. 28 (10): 3183–91. PMID 9808187. doi:10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A.
Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.". Blood. 97 (2): 352–8. PMID 11154208. doi:10.1182/blood.V97.2.352.
Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. PMID 11156964. doi:10.1096/fj.00-0354com.
Deregibus MC, Cantaluppi V, Doublier S, et al. (2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.". J. Biol. Chem. 277 (28): 25195–202. PMID 11994280. doi:10.1074/jbc.M200921200.
Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.". J. Immunol. 169 (1): 254–60. PMID 12077252. doi:10.4049/jimmunol.169.1.254.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
François F, Klotman ME (2003). "Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.". J. Virol. 77 (4): 2539–49. PMC 141101 . PMID 12551992. doi:10.1128/JVI.77.4.2539-2549.2003.
Vergne I, Chua J, Deretic V (2003). "Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade.". J. Exp. Med. 198 (4): 653–9. PMC 2194170 . PMID 12925680. doi:10.1084/jem.20030527.
Khan NA, Di Cello F, Nath A, Kim KS (2004). "Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells.". J. Neurovirol. 9 (6): 584–93. PMID 14602571. doi:10.1080/jnv.9.6.584.593.

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PIK3C3

References

Further reading