PHLPP (gene)

PHLPP1

Identifiers

PHLPP1, PHLPP, PLEKHE1, SCOP, PPM3A, PH domain and leucine rich repeat protein phosphatase 1

External IDs

MGI: 2138327 HomoloGene: 11015 GeneCards: PHLPP1

Gene location (Human)

Chr.	Chromosome 18 (human)^[1]

Band	No data available	Start	62,715,450 bp^[1]
Band	No data available	End	62,980,433 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	No data available	Start	106,171,752 bp^[2]
Band	No data available	End	106,394,250 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• phosphoprotein phosphatase activity • metal ion binding • protein binding • catalytic activity • hydrolase activity • protein serine/threonine phosphatase activity
Cellular component	• cytosol • membrane • nucleus • cytoplasm • plasma membrane • nuclear membrane
Biological process	• regulation of apoptotic process • negative regulation of protein kinase B signaling • regulation of MAPK cascade • protein dephosphorylation • entrainment of circadian clock • regulation of JNK cascade • regulation of T cell anergy • regulation of p38MAPK cascade • apoptotic process • regulation of protein kinase C signaling
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


23239


98432


ENSG00000081913


ENSMUSG00000044340


O60346


Q8CHE4

RefSeq (mRNA)


NM_194449


NM_133821

RefSeq (protein)


NP_919431


NP_598582

Location (UCSC)

Chr 18: 62.72 – 62.98 Mb

Chr 18: 106.17 – 106.39 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

PH domain and leucine rich repeat protein phosphatase, also known as PHLPP, is an enzyme which in humans is encoded by the PHLPP gene.^[5]

See also

PHLPP

References

Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954. doi:10.1093/dnares/9.3.99.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581. doi:10.1093/dnares/5.1.31.
Shimizu K, Okada M, Takano A, Nagai K (2000). "SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus.". FEBS Lett. 458 (3): 363–9. PMID 10570941. doi:10.1016/S0014-5793(99)01190-4.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Gao T, Furnari F, Newton AC (2005). "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.". Mol. Cell. 18 (1): 13–24. PMID 15808505. doi:10.1016/j.molcel.2005.03.008.
Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics. 4 (9): 1240–50. PMID 15951569. doi:10.1074/mcp.M500089-MCP200.
Nusbaum C, Zody MC, Borowsky ML, et al. (2005). "DNA sequence and analysis of human chromosome 18.". Nature. 437 (7058): 551–5. PMID 16177791. doi:10.1038/nature03983.
Brognard J, Sierecki E, Gao T, Newton AC (2007). "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.". Mol. Cell. 25 (6): 917–31. PMID 17386267. doi:10.1016/j.molcel.2007.02.017.

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