PHLPPL

PHLPP2

Identifiers

PHLPP2, PHLPPL, PPM3B, PH domain and leucine rich repeat protein phosphatase 2

External IDs

MGI: 2444928 HomoloGene: 71015 GeneCards: PHLPP2

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	No data available	Start	71,637,835 bp^[1]
Band	No data available	End	71,724,701 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	No data available	Start	109,868,542 bp^[2]
Band	No data available	End	109,944,671 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• catalytic activity • phosphoprotein phosphatase activity • hydrolase activity • metal ion binding • protein binding • protein serine/threonine phosphatase activity
Cellular component	• cytoplasm • cytosol • membrane • nucleus • photoreceptor inner segment • photoreceptor outer segment membrane
Biological process	• hippocampus development • protein dephosphorylation • signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23035


244650

Ensembl


ENSG00000040199


ENSMUSG00000031732

UniProt


Q6ZVD8


Q8BXA7

RefSeq (mRNA)


NM_015020 NM_001289003


NM_001122594

RefSeq (protein)


NP_001275932 NP_055835


NP_001116066

Location (UCSC)

Chr 16: 71.64 – 71.72 Mb

Chr 16: 109.87 – 109.94 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

PH domain and leucine rich repeat protein phosphatase-like, also known as PHLPPL, is an enzyme which in humans is encoded by the PHLPPL gene.^[5]

References

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032. doi:10.1093/dnares/6.1.63.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16.". Nature. 432 (7020): 988–94. PMID 15616553. doi:10.1038/nature03187.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
Brognard J, Sierecki E, Gao T, Newton AC (2007). "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.". Mol. Cell. 25 (6): 917–31. PMID 17386267. doi:10.1016/j.molcel.2007.02.017.
Rizvi F, Shukla S, Kakkar P (2014). "Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity.". Cell Death Dis. 5: e1153. PMC 3973230 . PMID 24675471. doi:10.1038/cddis.2014.118.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

PHLPPL

See also

References

Further reading